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Endurance training improves insulin sensitivity and body composition in prostate cancer patients treated with androgen deprivation therapy

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Insulin resistance and changes in body composition are side effects of androgen deprivation therapy (ADT) given to prostate cancer patients. The present study investigated whether endurance training improves insulin sensitivity and body composition in ADT-treated prostate cancer patients. Nine men undergoing ADT for prostate cancer and ten healthy men with normal testosterone levels underwent 12 weeks of endurance training. Primary endpoints were insulin sensitivity (euglycemic-hyperinsulinemic clamps with concomitant glucose-tracer infusion) and body composition (dual-energy X-ray absorptiometry and magnetic resonance imaging). The secondary endpoint was systemic inflammation. Statistical analysis was carried out using two-way ANOVA. Endurance training increased VO2max (ml(O2)/min per kg) by 11 and 13% in the patients and controls respectively (P
Original languageEnglish
JournalEndocrine - Related Cancer
Volume20
Issue number5
Pages (from-to)621-32
Number of pages12
ISSN1351-0088
DOIs
Publication statusPublished - 19 Aug 2013

ID: 38954474