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Endurance training enhances skeletal muscle interleukin-15 in human male subjects

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Regular endurance exercise promotes metabolic and oxidative changes in skeletal muscle. Overexpression of interleukin-15 (IL-15) in mice exerts similar metabolic changes in muscle as seen with endurance exercise. Muscular IL-15 production has been shown to increase in mice after weeks of regular endurance running. With the present study we aimed to determine if muscular IL-15 production would increase in human male subjects following 12 weeks of endurance training. In two different studies we obtained plasma and muscle biopsies from young healthy subjects performing: (1) 12 weeks of ergometer cycling exercise five times per week with plasma and biopsies before and after the intervention, and (2) 3 h of ergometer cycling exercise with plasma and biopsies before and after the exercise bout and well into recovery. We measured changes in plasma IL-15, muscle IL-15 mRNA and IL-15 protein. Twelve weeks of regular endurance training induced a 40% increase in basal skeletal muscle IL-15 protein content (p < 0.01), but with no changes in either muscle IL-15 mRNA or plasma IL-15 levels. However, an acute bout of 3-h exercise did not show significant changes in muscle IL-15 or plasma IL-15 levels. The induction of muscle IL-15 protein in humans following a regular training period supports previous findings in mice and emphasizes the hypothesis of IL-15 taking part in skeletal muscle adaptation during training.

Original languageEnglish
JournalEndocrine
Volume45
Issue number2
Pages (from-to)271-8
Number of pages8
ISSN1355-008X
DOIs
Publication statusPublished - Mar 2014

    Research areas

  • Adaptation, Physiological, Adult, Biopsy, Exercise, Exercise Test, Humans, Interleukin-15, Male, Muscle, Skeletal, Physical Endurance, RNA, Messenger, Time Factors, Up-Regulation

ID: 45075707