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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Endothelial nitric oxide synthase phosphorylation at Threonine 495 and mitochondrial reactive oxygen species formation in response to a high H₂O₂ concentration

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DOI

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Hydrogen peroxide (H₂O₂) is produced in vessels during ischemia/reperfusion and during inflammation, both leading to vascular dysfunction. We investigated cellular pathways involved in endothelial nitric oxide synthase (eNOS) phosphorylation at Threonine 495 (Thr(495)) in human umbilical vein endothelial cells (HUVECs) exposed to H₂O₂.
Original languageEnglish
JournalJournal of Vascular Research
Volume50
Issue number5
Pages (from-to)410-20
Number of pages11
ISSN1018-1172
DOIs
Publication statusPublished - 2013

    Research areas

  • Acetylcysteine, Butadienes, Cells, Cultured, Human Umbilical Vein Endothelial Cells, Humans, Hydrogen Peroxide, Indoles, MAP Kinase Kinase Kinases, Maleimides, Mitochondria, Nitric Oxide Synthase Type III, Nitriles, Phosphorylation, Protein Kinase C, Reactive Oxygen Species, Threonine, rho-Associated Kinases

ID: 42511056