Endophthalmitis following same-day bilateral anti-VEGF injections: a systematic review


PURPOSE: To review the risk of endophthalmitis in same-day bilateral anti-VEGF injections.

METHODS: We searched 12 literature databases for studies on the risk of endophthalmitis after same-day bilateral intravitreal anti-VEGF injections. Data extraction was made independently by two authors and discussed afterward until reaching consensus.

RESULTS: Seventeen studies were included with a total of 138,478 intravitreal anti-VEGF injections (69,239 bilateral injections sessions) given in at least 7579 patients. In total, 33 cases of endophthalmitis had occurred, and no cases were bilateral. The incidence of endophthalmitis ranged from 0 to 0.53% per intravitreal injection across studies.

CONCLUSIONS: We suggest that clinicians can consider same-day treatment of both eyes of patients in need of bilateral intravitreal anti-VEGF injection therapy, but larger studies are needed to quantify the exact risk of endophthalmitis.

Original languageEnglish
Article number37
JournalInternational Ophthalmology
Issue number1
Pages (from-to)37
Publication statusPublished - 8 Feb 2024


Dive into the research topics of 'Endophthalmitis following same-day bilateral anti-VEGF injections: a systematic review'. Together they form a unique fingerprint.

Cite this