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ENDO-ERN expert opinion on the differential diagnosis of pubertal delay

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  • Luca Persani
  • Marco Bonomi
  • Martine Cools
  • Mehul Dattani
  • Leo Dunkel
  • Claus H Gravholt
  • Anders Juul
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The differential diagnoses of pubertal delay include hypergonadotropic hypogonadism and congenital hypogonadotropic hypogonadism (CHH), as well as constitutional delay of growth and puberty (CDGP). Distinguishing between CDGP and CHH may be challenging, and the scientific community has been struggling to develop diagnostic tests that allow an accurate differential diagnosis. Indeed, an adequate and timely management is critical in order to enable optimal clinical and psychosocial outcomes of the different forms of pubertal delays. In this review, we provide an updated insight on the differential diagnoses of pubertal delay, including the available tests, their meanings and accuracy, as well as some clues to effectively orientate towards either constitutional pubertal delay or pathologic CHH and hypergonadotropic hypogonadism.

Original languageEnglish
JournalEndocrine
Volume71
Issue number3
Pages (from-to)681-688
Number of pages8
ISSN1355-008X
DOIs
Publication statusPublished - Mar 2021

Bibliographical note

Publisher Copyright:
© 2021, The Author(s).

Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.

    Research areas

  • Constitutional delay of growth and puberty, Gonadal dysgenesis, Hypogonadism, Primary ovarian insufficiency, Pubertal delay, Sex steroid priming

ID: 63790504