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Endocrine evaluation of reproductive function in girls during infancy, childhood and adolescence

Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

DOI

  1. Growth and Adult Height in Girls With Turner Syndrome Following IGF-1 Titrated Growth Hormone Treatment

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  2. Distinguishing between hidden testes and anorchia: The role of endocrine evaluation in infancy and childhood

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  3. Heritability of pubertal timing: detailed evaluation of specific milestones in healthy boys and girls

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  4. Predicting Transdermal Uptake of Phthalates and a Paraben from Cosmetic Cream Using the Measured Fugacity

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Puberty is characterized by a series a hormonal events leading to the attainment of adult reproductive capacity. Clinical manifestations of the pubertal processes include breast development, pubic hair development, menarche and regular menstrual bleedings. Abnormal pubertal development includes a spectrum of disorders such as premature thelarche, premature adrenarche, central and peripheral precocious puberty, adolescent polycystic ovarian syndrome, functional ovarian hyperandrogenism, late-onset congenital adrenal hyperplasia, primary and secondary amenorrhea, and premature ovarian insufficiency. Diagnosis of these reproductive disorders includes biochemical as well as clinical evaluation. The biochemical evaluation of reproductive function includes measurement of basal reproductive hormone levels and dynamic pituitary or adrenal hormone testing. Correct interpretation of such test results requires detailed knowledge on the normal maturational changes in the hypothalamic-pituitary-ovarian and hypothalamic-pituitary-adrenal axes. Changes in basal reproductive hormone levels in infancy, childhood and adolescence as well as the GnRH and ACTH test procedures in girls and adolescents are described in this chapter.
Original languageEnglish
Title of host publicationPediatric and Adolescent Gynecology
Number of pages16
Volume22
Publication date2012
Pages24-39
DOIs
Publication statusPublished - 2012
SeriesEndocrine Development
ISSN1421-7082

    Research areas

  • Adolescent, Adolescent Development, Adult, Child, Child, Preschool, Diagnostic Techniques, Endocrine, Female, Humans, Infant, Infant, Newborn, Models, Biological, Reproduction

ID: 31060037