EndoCompass project: research roadmap for thyroid endocrinology

Agnieszka Piekiełko-Witkowska; Rossella Elisei; Juliane Leger; Běla Bendlová; Barbora Bulanová Pekova; Philippe Caron; Cosimo Durante; Martin Fassnacht; Ulla Feldt-Rasmussen; Helena Filipsson Nyström; Heleen Jansen; Josef Köhrle; Aleksander Kuś; Marian Ludgate; Jonathan Mertens; Małgorzata Oczko-Wojciechowska; Catherine Peters; Nadia Schoenmakers; Athanasia Stoupa; Hanneke van Santen; Pierpaolo Trimboli; Paul van Trotsenburg; W Edward Visser

doi:10.1093/ejendo/lvaf010

EndoCompass project: research roadmap for thyroid endocrinology

Agnieszka Piekiełko-Witkowska, Rossella Elisei^*, Juliane Leger, Běla Bendlová, Barbora Bulanová Pekova, Philippe Caron, Cosimo Durante, Martin Fassnacht, Ulla Feldt-Rasmussen, Helena Filipsson Nyström, Heleen Jansen, Josef Köhrle, Aleksander Kuś, Marian Ludgate, Jonathan Mertens, Małgorzata Oczko-Wojciechowska, Catherine Peters, Nadia Schoenmakers, Athanasia Stoupa, Hanneke van SantenPierpaolo Trimboli, Paul van Trotsenburg, W Edward Visser

^*Corresponding author for this work

Department of Kidney and Hormone Diseases

Abstract

BACKGROUND: Endocrine science remains underrepresented in European Union research programs despite the fundamental role of hormone health in human well-being. Analysis of the CORDIS database reveals a persistent gap between the societal impact of endocrine disorders and their research prioritization. At national funding level, endocrine societies report limited or little attention of national research funding toward endocrinology. The EndoCompass project-a joint initiative between the European Society of Endocrinology and the European Society of Paediatric Endocrinology, aimed to identify and promote strategic research priorities in endocrine science to address critical hormone-related health challenges.

METHODS: Research priorities were established through comprehensive analysis of the EU CORDIS database covering the Horizon 2020 framework period (2014-2020). Expert consultation in thyroid endocrinology was conducted to identify key research priorities, followed by broader stakeholder engagement including society members and patient advocacy groups.

RESULTS: For thyroid disorders, research priorities encompass neoplastic and nonneoplastic conditions, focusing on disease mechanisms, improved diagnostics and treatments, and the impact of environmental and metabolic factors. Key areas include personalized medicine approaches, artificial intelligence applications, and the establishment of pan-European registries to advance understanding of rare thyroid conditions.

CONCLUSIONS: The thyroid component of the EndoCompass project provides an evidence-based roadmap for strategic research investment. This framework identifies crucial investigation areas into thyroid disease pathophysiology, prevention, and treatment strategies, ultimately aimed at reducing the burden of thyroid disorders on individuals and society. The findings support the broader EndoCompass objective of aligning research funding with areas of highest potential impact in endocrine health.

Original language	English
Journal	European Journal of Endocrinology
Volume	193
Issue number	Supplement_2
Pages (from-to)	ii117-ii127
ISSN	0804-4643
DOIs	https://doi.org/10.1093/ejendo/lvaf010
Publication status	Published - 17 Oct 2025

Keywords

Humans
Endocrinology/trends
Thyroid Diseases/therapy
Biomedical Research/trends
European Union
Databases, Factual
autoimmune thyroid disease
endocrine-disrupting chemicals
thyroid cancer
congenital hypothyroidism
microbiome
Hashimoto's thyroiditis
subclinical thyroid disease
thyroid
Graves’ disease
medullary thyroid cancer

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10.1093/ejendo/lvaf010Licence: CC BY

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Piekiełko-Witkowska, A., Elisei, R., Leger, J., Bendlová, B., Pekova, B. B., Caron, P., Durante, C., Fassnacht, M., Feldt-Rasmussen, U., Nyström, H. F., Jansen, H., Köhrle, J., Kuś, A., Ludgate, M., Mertens, J., Oczko-Wojciechowska, M., Peters, C., Schoenmakers, N., Stoupa, A., ... Edward Visser, W. (2025). EndoCompass project: research roadmap for thyroid endocrinology. European Journal of Endocrinology, 193(Supplement_2), ii117-ii127. https://doi.org/10.1093/ejendo/lvaf010

Piekiełko-Witkowska, A, Elisei, R, Leger, J, Bendlová, B, Pekova, BB, Caron, P, Durante, C, Fassnacht, M, Feldt-Rasmussen, U, Nyström, HF, Jansen, H, Köhrle, J, Kuś, A, Ludgate, M, Mertens, J, Oczko-Wojciechowska, M, Peters, C, Schoenmakers, N, Stoupa, A, van Santen, H, Trimboli, P, van Trotsenburg, P & Edward Visser, W 2025, 'EndoCompass project: research roadmap for thyroid endocrinology', European Journal of Endocrinology, vol. 193, no. Supplement_2, pp. ii117-ii127. https://doi.org/10.1093/ejendo/lvaf010

@article{55dbfcddf6c64c2c8b202a642b11268e,

title = "EndoCompass project: research roadmap for thyroid endocrinology",

abstract = "BACKGROUND: Endocrine science remains underrepresented in European Union research programs despite the fundamental role of hormone health in human well-being. Analysis of the CORDIS database reveals a persistent gap between the societal impact of endocrine disorders and their research prioritization. At national funding level, endocrine societies report limited or little attention of national research funding toward endocrinology. The EndoCompass project-a joint initiative between the European Society of Endocrinology and the European Society of Paediatric Endocrinology, aimed to identify and promote strategic research priorities in endocrine science to address critical hormone-related health challenges.METHODS: Research priorities were established through comprehensive analysis of the EU CORDIS database covering the Horizon 2020 framework period (2014-2020). Expert consultation in thyroid endocrinology was conducted to identify key research priorities, followed by broader stakeholder engagement including society members and patient advocacy groups.RESULTS: For thyroid disorders, research priorities encompass neoplastic and nonneoplastic conditions, focusing on disease mechanisms, improved diagnostics and treatments, and the impact of environmental and metabolic factors. Key areas include personalized medicine approaches, artificial intelligence applications, and the establishment of pan-European registries to advance understanding of rare thyroid conditions.CONCLUSIONS: The thyroid component of the EndoCompass project provides an evidence-based roadmap for strategic research investment. This framework identifies crucial investigation areas into thyroid disease pathophysiology, prevention, and treatment strategies, ultimately aimed at reducing the burden of thyroid disorders on individuals and society. The findings support the broader EndoCompass objective of aligning research funding with areas of highest potential impact in endocrine health.",

keywords = "Humans, Endocrinology/trends, Thyroid Diseases/therapy, Biomedical Research/trends, European Union, Databases, Factual, autoimmune thyroid disease, endocrine-disrupting chemicals, thyroid cancer, congenital hypothyroidism, microbiome, Hashimoto's thyroiditis, subclinical thyroid disease, thyroid, Graves{\textquoteright} disease, medullary thyroid cancer",

author = "Agnieszka Piekie{\l}ko-Witkowska and Rossella Elisei and Juliane Leger and B{\v e}la Bendlov{\'a} and Pekova, \{Barbora Bulanov{\'a}\} and Philippe Caron and Cosimo Durante and Martin Fassnacht and Ulla Feldt-Rasmussen and Nystr{\"o}m, \{Helena Filipsson\} and Heleen Jansen and Josef K{\"o}hrle and Aleksander Ku{\'s} and Marian Ludgate and Jonathan Mertens and Ma{\l}gorzata Oczko-Wojciechowska and Catherine Peters and Nadia Schoenmakers and Athanasia Stoupa and \{van Santen\}, Hanneke and Pierpaolo Trimboli and \{van Trotsenburg\}, Paul and \{Edward Visser\}, W",

note = "{\textcopyright} The Author(s) 2025. Published by Oxford University Press on behalf of European Society of Endocrinology.",

year = "2025",

month = oct,

day = "17",

doi = "10.1093/ejendo/lvaf010",

language = "English",

volume = "193",

pages = "ii117--ii127",

journal = "European Journal of Endocrinology",

issn = "0804-4643",

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TY - JOUR

T1 - EndoCompass project

T2 - research roadmap for thyroid endocrinology

AU - Piekiełko-Witkowska, Agnieszka

AU - Elisei, Rossella

AU - Leger, Juliane

AU - Bendlová, Běla

AU - Pekova, Barbora Bulanová

AU - Caron, Philippe

AU - Durante, Cosimo

AU - Fassnacht, Martin

AU - Feldt-Rasmussen, Ulla

AU - Nyström, Helena Filipsson

AU - Jansen, Heleen

AU - Köhrle, Josef

AU - Kuś, Aleksander

AU - Ludgate, Marian

AU - Mertens, Jonathan

AU - Oczko-Wojciechowska, Małgorzata

AU - Peters, Catherine

AU - Schoenmakers, Nadia

AU - Stoupa, Athanasia

AU - van Santen, Hanneke

AU - Trimboli, Pierpaolo

AU - van Trotsenburg, Paul

AU - Edward Visser, W

N1 - © The Author(s) 2025. Published by Oxford University Press on behalf of European Society of Endocrinology.

PY - 2025/10/17

Y1 - 2025/10/17

N2 - BACKGROUND: Endocrine science remains underrepresented in European Union research programs despite the fundamental role of hormone health in human well-being. Analysis of the CORDIS database reveals a persistent gap between the societal impact of endocrine disorders and their research prioritization. At national funding level, endocrine societies report limited or little attention of national research funding toward endocrinology. The EndoCompass project-a joint initiative between the European Society of Endocrinology and the European Society of Paediatric Endocrinology, aimed to identify and promote strategic research priorities in endocrine science to address critical hormone-related health challenges.METHODS: Research priorities were established through comprehensive analysis of the EU CORDIS database covering the Horizon 2020 framework period (2014-2020). Expert consultation in thyroid endocrinology was conducted to identify key research priorities, followed by broader stakeholder engagement including society members and patient advocacy groups.RESULTS: For thyroid disorders, research priorities encompass neoplastic and nonneoplastic conditions, focusing on disease mechanisms, improved diagnostics and treatments, and the impact of environmental and metabolic factors. Key areas include personalized medicine approaches, artificial intelligence applications, and the establishment of pan-European registries to advance understanding of rare thyroid conditions.CONCLUSIONS: The thyroid component of the EndoCompass project provides an evidence-based roadmap for strategic research investment. This framework identifies crucial investigation areas into thyroid disease pathophysiology, prevention, and treatment strategies, ultimately aimed at reducing the burden of thyroid disorders on individuals and society. The findings support the broader EndoCompass objective of aligning research funding with areas of highest potential impact in endocrine health.

AB - BACKGROUND: Endocrine science remains underrepresented in European Union research programs despite the fundamental role of hormone health in human well-being. Analysis of the CORDIS database reveals a persistent gap between the societal impact of endocrine disorders and their research prioritization. At national funding level, endocrine societies report limited or little attention of national research funding toward endocrinology. The EndoCompass project-a joint initiative between the European Society of Endocrinology and the European Society of Paediatric Endocrinology, aimed to identify and promote strategic research priorities in endocrine science to address critical hormone-related health challenges.METHODS: Research priorities were established through comprehensive analysis of the EU CORDIS database covering the Horizon 2020 framework period (2014-2020). Expert consultation in thyroid endocrinology was conducted to identify key research priorities, followed by broader stakeholder engagement including society members and patient advocacy groups.RESULTS: For thyroid disorders, research priorities encompass neoplastic and nonneoplastic conditions, focusing on disease mechanisms, improved diagnostics and treatments, and the impact of environmental and metabolic factors. Key areas include personalized medicine approaches, artificial intelligence applications, and the establishment of pan-European registries to advance understanding of rare thyroid conditions.CONCLUSIONS: The thyroid component of the EndoCompass project provides an evidence-based roadmap for strategic research investment. This framework identifies crucial investigation areas into thyroid disease pathophysiology, prevention, and treatment strategies, ultimately aimed at reducing the burden of thyroid disorders on individuals and society. The findings support the broader EndoCompass objective of aligning research funding with areas of highest potential impact in endocrine health.

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KW - Endocrinology/trends

KW - Thyroid Diseases/therapy

KW - Biomedical Research/trends

KW - European Union

KW - Databases, Factual

KW - autoimmune thyroid disease

KW - endocrine-disrupting chemicals

KW - thyroid cancer

KW - congenital hypothyroidism

KW - microbiome

KW - Hashimoto's thyroiditis

KW - subclinical thyroid disease

KW - thyroid

KW - Graves’ disease

KW - medullary thyroid cancer

UR - https://www.scopus.com/pages/publications/105019114482

U2 - 10.1093/ejendo/lvaf010

DO - 10.1093/ejendo/lvaf010

M3 - Journal article

C2 - 41104474

SN - 0804-4643

VL - 193

SP - ii117-ii127

JO - European Journal of Endocrinology

JF - European Journal of Endocrinology

IS - Supplement_2

ER -

EndoCompass project: research roadmap for thyroid endocrinology

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