EndoCompass project: environmental endocrinology

Anna-Maria Andersson; Stefano Cianfarani; Josef Köhrle; Katharina M Main; Anne-Simone Parent; Robin Peeters; Martin Reincke; Kristina Saravinovska; Maria E Street

doi:10.1093/ejendo/lvaf071

EndoCompass project: environmental endocrinology

Anna-Maria Andersson^*, Stefano Cianfarani, Josef Köhrle, Katharina M Main, Anne-Simone Parent, Robin Peeters, Martin Reincke, Kristina Saravinovska, Maria E Street

^*Corresponding author for this work

Department of Growth and Reproduction
EDMaRC - International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health

1 Citation (Scopus)

Abstract

BACKGROUND: Endocrine science remains underrepresented in European Union research programmes despite the fundamental role of hormone health in human well-being. Analysis of the CORDIS database reveals a persistent gap between the societal impact of endocrine disorders and their research prioritization. At national funding level, endocrine societies report limited or little attention of national research funding towards endocrinology. The EndoCompass project-a joint initiative between the European Society of Endocrinology and the European Society of Paediatric Endocrinology, aimed to identify and promote strategic research priorities in endocrine science to address critical hormone-related health challenges.

METHODS: Research priorities were established through a comprehensive analysis of the EU CORDIS database covering the Horizon 2020 framework period (2014-2020). An expert analysis was conducted by leading researchers in environmental endocrinology, integrating literature review, epidemiological evidence, and emerging research priorities to identify key challenges and opportunities across endocrine systems.

RESULTS: Research priorities span 5 critical domains: mechanisms and biomarkers of endocrine-disrupting chemical (EDC) actions; environmental pharmaceutical contamination; climate change effects on endocrine function; endocrine consequences of air and water pollution; and mechanisms linking environmental stress to hormone disruption. Special emphasis is placed on understanding developmental programming, transgenerational effects, and implications for public health policy.

CONCLUSIONS: This component of the EndoCompass project provides an evidence-based roadmap for strategic research investment. The analysis demonstrates that environmental factors like EDCs fundamentally impact multiple endocrine systems, requiring coordinated research approaches. The findings support the broader EndoCompass objective of aligning research funding with areas of highest potential impact in endocrine health.

Original language	English
Journal	European Journal of Endocrinology
Volume	193
Issue number	Supplement_2
Pages (from-to)	ii132-ii152
ISSN	0804-4643
DOIs	https://doi.org/10.1093/ejendo/lvaf071
Publication status	Published - 17 Oct 2025

Keywords

Humans
Endocrinology/trends
Endocrine Disruptors/toxicity
Endocrine System Diseases/epidemiology
European Union
Environmental Exposure/adverse effects
Biomedical Research
Climate Change
Databases, Factual
EDC
roadmap
EndoCompass
environment

Access to Document

10.1093/ejendo/lvaf071Licence: CC BY

Cite this

@article{2297c2b1eadb47e18c4437fc809974ad,

title = "EndoCompass project: environmental endocrinology",

abstract = "BACKGROUND: Endocrine science remains underrepresented in European Union research programmes despite the fundamental role of hormone health in human well-being. Analysis of the CORDIS database reveals a persistent gap between the societal impact of endocrine disorders and their research prioritization. At national funding level, endocrine societies report limited or little attention of national research funding towards endocrinology. The EndoCompass project-a joint initiative between the European Society of Endocrinology and the European Society of Paediatric Endocrinology, aimed to identify and promote strategic research priorities in endocrine science to address critical hormone-related health challenges.METHODS: Research priorities were established through a comprehensive analysis of the EU CORDIS database covering the Horizon 2020 framework period (2014-2020). An expert analysis was conducted by leading researchers in environmental endocrinology, integrating literature review, epidemiological evidence, and emerging research priorities to identify key challenges and opportunities across endocrine systems.RESULTS: Research priorities span 5 critical domains: mechanisms and biomarkers of endocrine-disrupting chemical (EDC) actions; environmental pharmaceutical contamination; climate change effects on endocrine function; endocrine consequences of air and water pollution; and mechanisms linking environmental stress to hormone disruption. Special emphasis is placed on understanding developmental programming, transgenerational effects, and implications for public health policy.CONCLUSIONS: This component of the EndoCompass project provides an evidence-based roadmap for strategic research investment. The analysis demonstrates that environmental factors like EDCs fundamentally impact multiple endocrine systems, requiring coordinated research approaches. The findings support the broader EndoCompass objective of aligning research funding with areas of highest potential impact in endocrine health.",

keywords = "Humans, Endocrinology/trends, Endocrine Disruptors/toxicity, Endocrine System Diseases/epidemiology, European Union, Environmental Exposure/adverse effects, Biomedical Research, Climate Change, Databases, Factual, EDC, roadmap, EndoCompass, environment",

author = "Anna-Maria Andersson and Stefano Cianfarani and Josef K{\"o}hrle and Main, \{Katharina M\} and Anne-Simone Parent and Robin Peeters and Martin Reincke and Kristina Saravinovska and Street, \{Maria E\}",

note = "{\textcopyright} The Author(s) 2025. Published by Oxford University Press on behalf of European Society of Endocrinology.",

year = "2025",

month = oct,

day = "17",

doi = "10.1093/ejendo/lvaf071",

language = "English",

volume = "193",

pages = "ii132--ii152",

journal = "European Journal of Endocrinology",

issn = "0804-4643",

publisher = "BioScientifica Ltd.",

number = "Supplement\_2",

}

TY - JOUR

T1 - EndoCompass project

T2 - environmental endocrinology

AU - Andersson, Anna-Maria

AU - Cianfarani, Stefano

AU - Köhrle, Josef

AU - Main, Katharina M

AU - Parent, Anne-Simone

AU - Peeters, Robin

AU - Reincke, Martin

AU - Saravinovska, Kristina

AU - Street, Maria E

N1 - © The Author(s) 2025. Published by Oxford University Press on behalf of European Society of Endocrinology.

PY - 2025/10/17

Y1 - 2025/10/17

N2 - BACKGROUND: Endocrine science remains underrepresented in European Union research programmes despite the fundamental role of hormone health in human well-being. Analysis of the CORDIS database reveals a persistent gap between the societal impact of endocrine disorders and their research prioritization. At national funding level, endocrine societies report limited or little attention of national research funding towards endocrinology. The EndoCompass project-a joint initiative between the European Society of Endocrinology and the European Society of Paediatric Endocrinology, aimed to identify and promote strategic research priorities in endocrine science to address critical hormone-related health challenges.METHODS: Research priorities were established through a comprehensive analysis of the EU CORDIS database covering the Horizon 2020 framework period (2014-2020). An expert analysis was conducted by leading researchers in environmental endocrinology, integrating literature review, epidemiological evidence, and emerging research priorities to identify key challenges and opportunities across endocrine systems.RESULTS: Research priorities span 5 critical domains: mechanisms and biomarkers of endocrine-disrupting chemical (EDC) actions; environmental pharmaceutical contamination; climate change effects on endocrine function; endocrine consequences of air and water pollution; and mechanisms linking environmental stress to hormone disruption. Special emphasis is placed on understanding developmental programming, transgenerational effects, and implications for public health policy.CONCLUSIONS: This component of the EndoCompass project provides an evidence-based roadmap for strategic research investment. The analysis demonstrates that environmental factors like EDCs fundamentally impact multiple endocrine systems, requiring coordinated research approaches. The findings support the broader EndoCompass objective of aligning research funding with areas of highest potential impact in endocrine health.

AB - BACKGROUND: Endocrine science remains underrepresented in European Union research programmes despite the fundamental role of hormone health in human well-being. Analysis of the CORDIS database reveals a persistent gap between the societal impact of endocrine disorders and their research prioritization. At national funding level, endocrine societies report limited or little attention of national research funding towards endocrinology. The EndoCompass project-a joint initiative between the European Society of Endocrinology and the European Society of Paediatric Endocrinology, aimed to identify and promote strategic research priorities in endocrine science to address critical hormone-related health challenges.METHODS: Research priorities were established through a comprehensive analysis of the EU CORDIS database covering the Horizon 2020 framework period (2014-2020). An expert analysis was conducted by leading researchers in environmental endocrinology, integrating literature review, epidemiological evidence, and emerging research priorities to identify key challenges and opportunities across endocrine systems.RESULTS: Research priorities span 5 critical domains: mechanisms and biomarkers of endocrine-disrupting chemical (EDC) actions; environmental pharmaceutical contamination; climate change effects on endocrine function; endocrine consequences of air and water pollution; and mechanisms linking environmental stress to hormone disruption. Special emphasis is placed on understanding developmental programming, transgenerational effects, and implications for public health policy.CONCLUSIONS: This component of the EndoCompass project provides an evidence-based roadmap for strategic research investment. The analysis demonstrates that environmental factors like EDCs fundamentally impact multiple endocrine systems, requiring coordinated research approaches. The findings support the broader EndoCompass objective of aligning research funding with areas of highest potential impact in endocrine health.

KW - Humans

KW - Endocrinology/trends

KW - Endocrine Disruptors/toxicity

KW - Endocrine System Diseases/epidemiology

KW - European Union

KW - Environmental Exposure/adverse effects

KW - Biomedical Research

KW - Climate Change

KW - Databases, Factual

KW - EDC

KW - roadmap

KW - EndoCompass

KW - environment

UR - https://www.scopus.com/pages/publications/105019113842

U2 - 10.1093/ejendo/lvaf071

DO - 10.1093/ejendo/lvaf071

M3 - Journal article

C2 - 41104466

SN - 0804-4643

VL - 193

SP - ii132-ii152

JO - European Journal of Endocrinology

JF - European Journal of Endocrinology

IS - Supplement_2

ER -

EndoCompass project: environmental endocrinology

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this