Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital

Emotional cognition subgroups in mood disorders: Associations with familial risk

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Psilocybin-induced changes in brain network integrity and segregation correlate with plasma psilocin level and psychedelic experience

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Apps for mental health care: The raise of digital psychiatry

    Research output: Contribution to journalComment/debateResearchpeer-review

  1. Incomplete systematic review and meta-analysis on statin use and depression risk - A commentary

    Research output: Contribution to journalLetterResearchpeer-review

  2. Primary prevention of depression: An umbrella review of controlled interventions

    Research output: Contribution to journalReviewResearchpeer-review

  3. Autism comorbidities show elevated female-to-male odds ratios and are associated with the age of first autism diagnosis

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Risk of depression after diagnostic prostate cancer workup - A nationwide, registry-based study

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

Patients with mood disorders show heterogeneity in non-emotional cognition. However, it is unclear whether emotional cognition (EC) is characterised by similar heterogeneity. We aimed to investigate the heterogeneity in EC among remitted patients with mood disorders and explore its association with familial risk. Data from 269 partially or fully remitted patients with mood disorders, 87 of their unaffected relatives (UR) and 203 healthy controls (HC) were pooled from two cohort studies. Hierarchical cluster analysis was conducted using the EC data from patients. UR were categorised into groups consistent with their affected relatives' cluster assignment. Clusters were compared to HC on EC, non-emotional cognition, clinical characteristics and functioning. We identified three clusters: an 'emotionally preserved' (57%), an 'emotionally blunted' (26%) and an 'emotionally volatile' cluster (17%). 'Emotionally blunted' and 'emotionally volatile' patients also presented more deficits in non-emotional cognition (global cognition read z=-0.3 and -0.5 respectively). Relatives of 'emotionally preserved' patients were more successful at dampening negative emotions (p=.01, d=0.39, 95% CI [-0.76,-0.09]), whereas UR of 'emotionally impaired' patients underperformed in verbal fluency (p=.03, d=0.46, 95% CI [.03, 0.68]) compared to HC. The existence of impaired EC groups in remitted mood disorder highlights a need to screen for and treat EC in mood disorders. Improved ability to dampen emotions in UR of 'emotionally preserved' patients may reflect a resilience marker while impaired verbal fluency in UR of 'emotionally impaired' patients may reflect distinct genetic risk profiles in these EC subgroups.

Original languageEnglish
JournalEuropean neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology
Pages (from-to)71-83
Number of pages13
Publication statusPublished - Oct 2021

    Research areas

  • Cluster-analysis, Emotional cognition, Emotional processing, Emotional regulation, Mood disorders

ID: 67031101