Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Emergence of the G118R Pan-Integrase Resistance Mutation as a Result of Low Compliance to a Dolutegravir-Based cART

Research output: Contribution to journalJournal articlepeer-review

DOI

  1. High incidence of subclinical peripheral artery disease in people with HIV

    Research output: Contribution to journalJournal articlepeer-review

  2. Risk of subarachnoid haemorrhages and aneurysms in Danish people with HIV

    Research output: Contribution to journalJournal articlepeer-review

  3. Humoral response to two doses of BNT162b2 vaccination in people with HIV

    Research output: Contribution to journalJournal articlepeer-review

View graph of relations

HIV-1 resistance towards integrase inhibitors is a potential threat of the success of HIV-1 combination treatment. G118R is a rare drug resistance mutation conferring pan-integrase resistance. Here, we describe the occurrence of G118R in a HIV-1 subtype-B-positive individual with major compliance problems, detected while the patient was on dolutegravir-based cART. We speculate the pre-selection of M184I/V aided the occurrence of G118R in this case, and discuss the robustness of dolutegravir-based therapies.

Original languageEnglish
JournalInfectious disease reports
Volume14
Issue number4
Pages (from-to)501-504
Number of pages4
ISSN2036-7430
DOIs
Publication statusPublished - 22 Jun 2022

ID: 79929200