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Emergence and spread of a human-transmissible multidrug-resistant nontuberculous mycobacterium

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Harvard

Bryant, JM, Grogono, DM, Rodriguez-Rincon, D, Everall, I, Brown, KP, Moreno, P, Verma, D, Hill, E, Drijkoningen, J, Gilligan, P, Esther, CR, Noone, PG, Giddings, O, Bell, SC, Thomson, R, Wainwright, CE, Coulter, C, Pandey, S, Wood, ME, Stockwell, RE, Ramsay, KA, Sherrard, LJ, Kidd, TJ, Jabbour, N, Johnson, GR, Knibbs, LD, Morawska, L, Sly, PD, Jones, A, Bilton, D, Laurenson, I, Ruddy, M, Bourke, S, Bowler, ICJW, Chapman, SJ, Clayton, A, Cullen, M, Dempsey, O, Denton, M, Desai, M, Drew, RJ, Edenborough, F, Evans, J, Folb, J, Daniels, T, Humphrey, H, Isalska, B, Jensen-Fangel, S, Jönsson, B, Jones, AM, Katzenstein, TL, Lillebaek, T, MacGregor, G, Mayell, S, Millar, M, Modha, D, Nash, EF, O'Brien, C, O'Brien, D, Ohri, C, Pao, CS, Peckham, D, Perrin, F, Perry, A, Pressler, T, Prtak, L, Qvist, T, Robb, A, Rodgers, H, Schaffer, K, Shafi, N, van Ingen, J, Walshaw, M, Watson, D, West, N, Whitehouse, J, Haworth, CS, Harris, SR, Ordway, D, Parkhill, J & Floto, RA 2016, 'Emergence and spread of a human-transmissible multidrug-resistant nontuberculous mycobacterium' Science, vol. 354, no. 6313, pp. 751-757. https://doi.org/10.1126/science.aaf8156

APA

Bryant, J. M., Grogono, D. M., Rodriguez-Rincon, D., Everall, I., Brown, K. P., Moreno, P., ... Floto, R. A. (2016). Emergence and spread of a human-transmissible multidrug-resistant nontuberculous mycobacterium. Science, 354(6313), 751-757. https://doi.org/10.1126/science.aaf8156

CBE

Bryant JM, Grogono DM, Rodriguez-Rincon D, Everall I, Brown KP, Moreno P, Verma D, Hill E, Drijkoningen J, Gilligan P, Esther CR, Noone PG, Giddings O, Bell SC, Thomson R, Wainwright CE, Coulter C, Pandey S, Wood ME, Stockwell RE, Ramsay KA, Sherrard LJ, Kidd TJ, Jabbour N, Johnson GR, Knibbs LD, Morawska L, Sly PD, Jones A, Bilton D, Laurenson I, Ruddy M, Bourke S, Bowler ICJW, Chapman SJ, Clayton A, Cullen M, Dempsey O, Denton M, Desai M, Drew RJ, Edenborough F, Evans J, Folb J, Daniels T, Humphrey H, Isalska B, Jensen-Fangel S, Jönsson B, Jones AM, Katzenstein TL, Lillebaek T, MacGregor G, Mayell S, Millar M, Modha D, Nash EF, O'Brien C, O'Brien D, Ohri C, Pao CS, Peckham D, Perrin F, Perry A, Pressler T, Prtak L, Qvist T, Robb A, Rodgers H, Schaffer K, Shafi N, van Ingen J, Walshaw M, Watson D, West N, Whitehouse J, Haworth CS, Harris SR, Ordway D, Parkhill J, Floto RA. 2016. Emergence and spread of a human-transmissible multidrug-resistant nontuberculous mycobacterium. Science. 354(6313):751-757. https://doi.org/10.1126/science.aaf8156

MLA

Vancouver

Bryant JM, Grogono DM, Rodriguez-Rincon D, Everall I, Brown KP, Moreno P et al. Emergence and spread of a human-transmissible multidrug-resistant nontuberculous mycobacterium. Science. 2016 Nov 11;354(6313):751-757. https://doi.org/10.1126/science.aaf8156

Author

Bryant, Josephine M ; Grogono, Dorothy M ; Rodriguez-Rincon, Daniela ; Everall, Isobel ; Brown, Karen P ; Moreno, Pablo ; Verma, Deepshikha ; Hill, Emily ; Drijkoningen, Judith ; Gilligan, Peter ; Esther, Charles R ; Noone, Peadar G ; Giddings, Olivia ; Bell, Scott C ; Thomson, Rachel ; Wainwright, Claire E ; Coulter, Chris ; Pandey, Sushil ; Wood, Michelle E ; Stockwell, Rebecca E ; Ramsay, Kay A ; Sherrard, Laura J ; Kidd, Timothy J ; Jabbour, Nassib ; Johnson, Graham R ; Knibbs, Luke D ; Morawska, Lidia ; Sly, Peter D ; Jones, Andrew ; Bilton, Diana ; Laurenson, Ian ; Ruddy, Michael ; Bourke, Stephen ; Bowler, Ian C J W ; Chapman, Stephen J ; Clayton, Andrew ; Cullen, Mairi ; Dempsey, Owen ; Denton, Miles ; Desai, Maya ; Drew, Richard J ; Edenborough, Frank ; Evans, Jason ; Folb, Jonathan ; Daniels, Thomas ; Humphrey, Helen ; Isalska, Barbara ; Jensen-Fangel, Søren ; Jönsson, Bodil ; Jones, Andrew M ; Katzenstein, Terese L ; Lillebaek, Troels ; MacGregor, Gordon ; Mayell, Sarah ; Millar, Michael ; Modha, Deborah ; Nash, Edward F ; O'Brien, Christopher ; O'Brien, Deirdre ; Ohri, Chandra ; Pao, Caroline S ; Peckham, Daniel ; Perrin, Felicity ; Perry, Audrey ; Pressler, Tania ; Prtak, Laura ; Qvist, Tavs ; Robb, Ali ; Rodgers, Helen ; Schaffer, Kirsten ; Shafi, Nadia ; van Ingen, Jakko ; Walshaw, Martin ; Watson, Danie ; West, Noreen ; Whitehouse, Joanna ; Haworth, Charles S ; Harris, Simon R ; Ordway, Diane ; Parkhill, Julian ; Floto, R Andres. / Emergence and spread of a human-transmissible multidrug-resistant nontuberculous mycobacterium. In: Science. 2016 ; Vol. 354, No. 6313. pp. 751-757.

Bibtex

@article{9142a3fbe05b478e92eb828c99c86e4c,
title = "Emergence and spread of a human-transmissible multidrug-resistant nontuberculous mycobacterium",
abstract = "Lung infections with Mycobacterium abscessus, a species of multidrug-resistant nontuberculous mycobacteria, are emerging as an important global threat to individuals with cystic fibrosis (CF), in whom M. abscessus accelerates inflammatory lung damage, leading to increased morbidity and mortality. Previously, M. abscessus was thought to be independently acquired by susceptible individuals from the environment. However, using whole-genome analysis of a global collection of clinical isolates, we show that the majority of M. abscessus infections are acquired through transmission, potentially via fomites and aerosols, of recently emerged dominant circulating clones that have spread globally. We demonstrate that these clones are associated with worse clinical outcomes, show increased virulence in cell-based and mouse infection models, and thus represent an urgent international infection challenge.",
author = "Bryant, {Josephine M} and Grogono, {Dorothy M} and Daniela Rodriguez-Rincon and Isobel Everall and Brown, {Karen P} and Pablo Moreno and Deepshikha Verma and Emily Hill and Judith Drijkoningen and Peter Gilligan and Esther, {Charles R} and Noone, {Peadar G} and Olivia Giddings and Bell, {Scott C} and Rachel Thomson and Wainwright, {Claire E} and Chris Coulter and Sushil Pandey and Wood, {Michelle E} and Stockwell, {Rebecca E} and Ramsay, {Kay A} and Sherrard, {Laura J} and Kidd, {Timothy J} and Nassib Jabbour and Johnson, {Graham R} and Knibbs, {Luke D} and Lidia Morawska and Sly, {Peter D} and Andrew Jones and Diana Bilton and Ian Laurenson and Michael Ruddy and Stephen Bourke and Bowler, {Ian C J W} and Chapman, {Stephen J} and Andrew Clayton and Mairi Cullen and Owen Dempsey and Miles Denton and Maya Desai and Drew, {Richard J} and Frank Edenborough and Jason Evans and Jonathan Folb and Thomas Daniels and Helen Humphrey and Barbara Isalska and S{\o}ren Jensen-Fangel and Bodil J{\"o}nsson and Jones, {Andrew M} and Katzenstein, {Terese L} and Troels Lillebaek and Gordon MacGregor and Sarah Mayell and Michael Millar and Deborah Modha and Nash, {Edward F} and Christopher O'Brien and Deirdre O'Brien and Chandra Ohri and Pao, {Caroline S} and Daniel Peckham and Felicity Perrin and Audrey Perry and Tania Pressler and Laura Prtak and Tavs Qvist and Ali Robb and Helen Rodgers and Kirsten Schaffer and Nadia Shafi and {van Ingen}, Jakko and Martin Walshaw and Danie Watson and Noreen West and Joanna Whitehouse and Haworth, {Charles S} and Harris, {Simon R} and Diane Ordway and Julian Parkhill and Floto, {R Andres}",
note = "Copyright {\circledC} 2016, American Association for the Advancement of Science.",
year = "2016",
month = "11",
day = "11",
doi = "10.1126/science.aaf8156",
language = "English",
volume = "354",
pages = "751--757",
journal = "Science",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science",
number = "6313",

}

RIS

TY - JOUR

T1 - Emergence and spread of a human-transmissible multidrug-resistant nontuberculous mycobacterium

AU - Bryant, Josephine M

AU - Grogono, Dorothy M

AU - Rodriguez-Rincon, Daniela

AU - Everall, Isobel

AU - Brown, Karen P

AU - Moreno, Pablo

AU - Verma, Deepshikha

AU - Hill, Emily

AU - Drijkoningen, Judith

AU - Gilligan, Peter

AU - Esther, Charles R

AU - Noone, Peadar G

AU - Giddings, Olivia

AU - Bell, Scott C

AU - Thomson, Rachel

AU - Wainwright, Claire E

AU - Coulter, Chris

AU - Pandey, Sushil

AU - Wood, Michelle E

AU - Stockwell, Rebecca E

AU - Ramsay, Kay A

AU - Sherrard, Laura J

AU - Kidd, Timothy J

AU - Jabbour, Nassib

AU - Johnson, Graham R

AU - Knibbs, Luke D

AU - Morawska, Lidia

AU - Sly, Peter D

AU - Jones, Andrew

AU - Bilton, Diana

AU - Laurenson, Ian

AU - Ruddy, Michael

AU - Bourke, Stephen

AU - Bowler, Ian C J W

AU - Chapman, Stephen J

AU - Clayton, Andrew

AU - Cullen, Mairi

AU - Dempsey, Owen

AU - Denton, Miles

AU - Desai, Maya

AU - Drew, Richard J

AU - Edenborough, Frank

AU - Evans, Jason

AU - Folb, Jonathan

AU - Daniels, Thomas

AU - Humphrey, Helen

AU - Isalska, Barbara

AU - Jensen-Fangel, Søren

AU - Jönsson, Bodil

AU - Jones, Andrew M

AU - Katzenstein, Terese L

AU - Lillebaek, Troels

AU - MacGregor, Gordon

AU - Mayell, Sarah

AU - Millar, Michael

AU - Modha, Deborah

AU - Nash, Edward F

AU - O'Brien, Christopher

AU - O'Brien, Deirdre

AU - Ohri, Chandra

AU - Pao, Caroline S

AU - Peckham, Daniel

AU - Perrin, Felicity

AU - Perry, Audrey

AU - Pressler, Tania

AU - Prtak, Laura

AU - Qvist, Tavs

AU - Robb, Ali

AU - Rodgers, Helen

AU - Schaffer, Kirsten

AU - Shafi, Nadia

AU - van Ingen, Jakko

AU - Walshaw, Martin

AU - Watson, Danie

AU - West, Noreen

AU - Whitehouse, Joanna

AU - Haworth, Charles S

AU - Harris, Simon R

AU - Ordway, Diane

AU - Parkhill, Julian

AU - Floto, R Andres

N1 - Copyright © 2016, American Association for the Advancement of Science.

PY - 2016/11/11

Y1 - 2016/11/11

N2 - Lung infections with Mycobacterium abscessus, a species of multidrug-resistant nontuberculous mycobacteria, are emerging as an important global threat to individuals with cystic fibrosis (CF), in whom M. abscessus accelerates inflammatory lung damage, leading to increased morbidity and mortality. Previously, M. abscessus was thought to be independently acquired by susceptible individuals from the environment. However, using whole-genome analysis of a global collection of clinical isolates, we show that the majority of M. abscessus infections are acquired through transmission, potentially via fomites and aerosols, of recently emerged dominant circulating clones that have spread globally. We demonstrate that these clones are associated with worse clinical outcomes, show increased virulence in cell-based and mouse infection models, and thus represent an urgent international infection challenge.

AB - Lung infections with Mycobacterium abscessus, a species of multidrug-resistant nontuberculous mycobacteria, are emerging as an important global threat to individuals with cystic fibrosis (CF), in whom M. abscessus accelerates inflammatory lung damage, leading to increased morbidity and mortality. Previously, M. abscessus was thought to be independently acquired by susceptible individuals from the environment. However, using whole-genome analysis of a global collection of clinical isolates, we show that the majority of M. abscessus infections are acquired through transmission, potentially via fomites and aerosols, of recently emerged dominant circulating clones that have spread globally. We demonstrate that these clones are associated with worse clinical outcomes, show increased virulence in cell-based and mouse infection models, and thus represent an urgent international infection challenge.

U2 - 10.1126/science.aaf8156

DO - 10.1126/science.aaf8156

M3 - Journal article

VL - 354

SP - 751

EP - 757

JO - Science

JF - Science

SN - 0036-8075

IS - 6313

ER -

ID: 49761566