Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Emergence and spread of a human-transmissible multidrug-resistant nontuberculous mycobacterium

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Large-scale GWAS reveals insights into the genetic architecture of same-sex sexual behavior

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Analysis of shared heritability in common disorders of the brain

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Ancient genomes from Iceland reveal the making of a human population

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Shared molecular neuropathology across major psychiatric disorders parallels polygenic overlap

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Mouse models of acute and chronic hepacivirus infection

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. How to Identify Common Variable Immunodeficiency Patients Earlier: General Practice Patterns

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Syphilitic hepatitis and neurosyphilis: an observational study of Danish HIV-infected individuals during a 13-year period

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Markers of bone turnover are reduced in patients with CF related diabetes; the role of glucose

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Seasonal fluctuation of lung function in cystic fibrosis: A national register-based study in two northern European populations

    Research output: Contribution to journalJournal articleResearchpeer-review

  • Josephine M Bryant
  • Dorothy M Grogono
  • Daniela Rodriguez-Rincon
  • Isobel Everall
  • Karen P Brown
  • Pablo Moreno
  • Deepshikha Verma
  • Emily Hill
  • Judith Drijkoningen
  • Peter Gilligan
  • Charles R Esther
  • Peadar G Noone
  • Olivia Giddings
  • Scott C Bell
  • Rachel Thomson
  • Claire E Wainwright
  • Chris Coulter
  • Sushil Pandey
  • Michelle E Wood
  • Rebecca E Stockwell
  • Kay A Ramsay
  • Laura J Sherrard
  • Timothy J Kidd
  • Nassib Jabbour
  • Graham R Johnson
  • Luke D Knibbs
  • Lidia Morawska
  • Peter D Sly
  • Andrew Jones
  • Diana Bilton
  • Ian Laurenson
  • Michael Ruddy
  • Stephen Bourke
  • Ian C J W Bowler
  • Stephen J Chapman
  • Andrew Clayton
  • Mairi Cullen
  • Owen Dempsey
  • Miles Denton
  • Maya Desai
  • Richard J Drew
  • Frank Edenborough
  • Jason Evans
  • Jonathan Folb
  • Thomas Daniels
  • Helen Humphrey
  • Barbara Isalska
  • Søren Jensen-Fangel
  • Bodil Jönsson
  • Andrew M Jones
  • Terese L Katzenstein
  • Troels Lillebaek
  • Gordon MacGregor
  • Sarah Mayell
  • Michael Millar
  • Deborah Modha
  • Edward F Nash
  • Christopher O'Brien
  • Deirdre O'Brien
  • Chandra Ohri
  • Caroline S Pao
  • Daniel Peckham
  • Felicity Perrin
  • Audrey Perry
  • Tania Pressler
  • Laura Prtak
  • Tavs Qvist
  • Ali Robb
  • Helen Rodgers
  • Kirsten Schaffer
  • Nadia Shafi
  • Jakko van Ingen
  • Martin Walshaw
  • Danie Watson
  • Noreen West
  • Joanna Whitehouse
  • Charles S Haworth
  • Simon R Harris
  • Diane Ordway
  • Julian Parkhill
  • R Andres Floto
View graph of relations

Lung infections with Mycobacterium abscessus, a species of multidrug-resistant nontuberculous mycobacteria, are emerging as an important global threat to individuals with cystic fibrosis (CF), in whom M. abscessus accelerates inflammatory lung damage, leading to increased morbidity and mortality. Previously, M. abscessus was thought to be independently acquired by susceptible individuals from the environment. However, using whole-genome analysis of a global collection of clinical isolates, we show that the majority of M. abscessus infections are acquired through transmission, potentially via fomites and aerosols, of recently emerged dominant circulating clones that have spread globally. We demonstrate that these clones are associated with worse clinical outcomes, show increased virulence in cell-based and mouse infection models, and thus represent an urgent international infection challenge.

Original languageEnglish
JournalScience
Volume354
Issue number6313
Pages (from-to)751-757
Number of pages7
ISSN0036-8075
DOIs
Publication statusPublished - 11 Nov 2016

ID: 49761566