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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Emergence and spread of a human-transmissible multidrug-resistant nontuberculous mycobacterium

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  1. Deep sleep drives brain fluid oscillations

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  2. Chromosome errors in human eggs shape natural fertility over reproductive life span

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  3. Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility

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  4. Large-scale GWAS reveals insights into the genetic architecture of same-sex sexual behavior

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  5. Suicide-turning the tide

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  1. Children exposed or unexposed to HIV: weight, height and BMI during the first five years of life. A Danish Nationwide Cohort Study

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  2. Risk factors during pregnancy and birth-related complications in HIV-positive versus HIV-negative women in Denmark, 2002-2014

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  3. Cystic fibrosis newborn screening in Denmark: Experience from the first 2 years

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  4. Biofilms of Mycobacterium abscessus complex can be sensitized to antibiotics by disaggregation and oxygenation

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  5. Leptospirosis meningitis transmission from a pet mouse: a case report

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  • Josephine M Bryant
  • Dorothy M Grogono
  • Daniela Rodriguez-Rincon
  • Isobel Everall
  • Karen P Brown
  • Pablo Moreno
  • Deepshikha Verma
  • Emily Hill
  • Judith Drijkoningen
  • Peter Gilligan
  • Charles R Esther
  • Peadar G Noone
  • Olivia Giddings
  • Scott C Bell
  • Rachel Thomson
  • Claire E Wainwright
  • Chris Coulter
  • Sushil Pandey
  • Michelle E Wood
  • Rebecca E Stockwell
  • Kay A Ramsay
  • Laura J Sherrard
  • Timothy J Kidd
  • Nassib Jabbour
  • Graham R Johnson
  • Luke D Knibbs
  • Lidia Morawska
  • Peter D Sly
  • Andrew Jones
  • Diana Bilton
  • Ian Laurenson
  • Michael Ruddy
  • Stephen Bourke
  • Ian C J W Bowler
  • Stephen J Chapman
  • Andrew Clayton
  • Mairi Cullen
  • Owen Dempsey
  • Miles Denton
  • Maya Desai
  • Richard J Drew
  • Frank Edenborough
  • Jason Evans
  • Jonathan Folb
  • Thomas Daniels
  • Helen Humphrey
  • Barbara Isalska
  • Søren Jensen-Fangel
  • Bodil Jönsson
  • Andrew M Jones
  • Terese L Katzenstein
  • Troels Lillebaek
  • Gordon MacGregor
  • Sarah Mayell
  • Michael Millar
  • Deborah Modha
  • Edward F Nash
  • Christopher O'Brien
  • Deirdre O'Brien
  • Chandra Ohri
  • Caroline S Pao
  • Daniel Peckham
  • Felicity Perrin
  • Audrey Perry
  • Tania Pressler
  • Laura Prtak
  • Tavs Qvist
  • Ali Robb
  • Helen Rodgers
  • Kirsten Schaffer
  • Nadia Shafi
  • Jakko van Ingen
  • Martin Walshaw
  • Danie Watson
  • Noreen West
  • Joanna Whitehouse
  • Charles S Haworth
  • Simon R Harris
  • Diane Ordway
  • Julian Parkhill
  • R Andres Floto
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Lung infections with Mycobacterium abscessus, a species of multidrug-resistant nontuberculous mycobacteria, are emerging as an important global threat to individuals with cystic fibrosis (CF), in whom M. abscessus accelerates inflammatory lung damage, leading to increased morbidity and mortality. Previously, M. abscessus was thought to be independently acquired by susceptible individuals from the environment. However, using whole-genome analysis of a global collection of clinical isolates, we show that the majority of M. abscessus infections are acquired through transmission, potentially via fomites and aerosols, of recently emerged dominant circulating clones that have spread globally. We demonstrate that these clones are associated with worse clinical outcomes, show increased virulence in cell-based and mouse infection models, and thus represent an urgent international infection challenge.

Original languageEnglish
JournalScience
Volume354
Issue number6313
Pages (from-to)751-757
Number of pages7
ISSN0036-8075
DOIs
Publication statusPublished - 11 Nov 2016

ID: 49761566