Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Electroencephalographic Cross-Frequency Coupling as a Sign of Disease Progression in Patients With Mild Cognitive Impairment: A Pilot Study

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. In-vitro Recordings of Neural Magnetic Activity From the Auditory Brainstem Using Color Centers in Diamond: A Simulation Study

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Reduction of Pressure Pain Sensitivity as Novel Non-pharmacological Therapeutic Approach to Type 2 Diabetes: A Randomized Trial

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Feasibility of Glutamate and GABA Detection in Pons and Thalamus at 3T and 7T by Proton Magnetic Resonance Spectroscopy

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Untreated Patients Dying With AIDS Have Loss of Neocortical Neurons and Glia Cells

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Increased short- and long-term mortality following infections in dementia: a nationwide registry-based cohort study

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Cortical Frontoparietal Network Dysfunction in CHMP2B-Frontotemporal Dementia

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Upwards Drift of Cerebrospinal Fluid Amyloid-β 42 Over Twelve Years in a Consecutive Clinical Cohort

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Changes in the left temporal microstate are a sign of cognitive decline in patients with Alzheimer's disease

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Cerebrospinal Fluid/Plasma Albumin Ratio as a Biomarker for Blood-Brain Barrier Impairment Across Neurodegenerative Dementias

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

Mild cognitive impairment (MCI) refers to mild objective cognitive deficits and is associated with the later development of Alzheimer's disease (AD). However, not all patients with MCI convert to AD. EEG spectral power has shown promise as a marker of progression, but brain oscillations in different frequencies are not isolated entities. Coupling between different frequency bands, so-called cross-frequency coupling (CFC), has been associated with memory function and may further contribute to our understanding of what characterizes patients with MCI who progress to AD. In the current study, we wanted to investigate the changes in gamma/theta CFC in patients with AD and MCI compared to HC and in patients with pMCI compared to patients with sMCI. Furthermore, we wanted to investigate the association with cognitive test scores. EEGs were included at baseline for 15 patients with AD, 25 patients with MCI, and 36 older HC, and the participants were followed for up to 3 years. To investigate CFC, we calculated the modulation index (MI), which has been shown to be less affected by noisy data compared to other techniques. We found that patients with pMCI showed a significantly lower global gamma/theta CFC compared to patients with sMCI. In addition, global gamma/theta CFC was significantly correlated with Addenbrooke's Cognitive Examination (ACE) score (p-value = 0.030, rho = 0.527). Although not significant, patients with AD and MCI showed a lower gamma/theta CFC compared to HC. These findings suggest that gamma/theta CFC is important for proper cognitive functioning and that a decrease in gamma/theta CFC in patients with MCI may be a sign of progression. Gamma/theta CFC may therefore serve as a progression marker in MCI, but larger studies are needed to validate these findings.

Original languageEnglish
Article number790
JournalFrontiers in Neuroscience
Volume14
Pages (from-to)790
ISSN1662-4548
DOIs
Publication statusPublished - 11 Aug 2020

    Research areas

  • Alzheimer’s disease, cross-frequency coupling, gamma, mild cognitive impairment, phase-amplitude coupling, theta

ID: 61265567