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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Electrochemical sensing of biomarker for diagnostics of bacteria-specific infections

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  2. Structure of Pseudomonas aeruginosa ribosomes from an aminoglycoside-resistant clinical isolate

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AIM: Pseudomonas aeruginosa is a pathogen that is prevalent in serious infections in compromised patients worldwide. A unique virulence factor of this bacterium is the redox-active molecule pyocyanin, which is a potential biomarker for the identification of P. aeruginosa infections. Here we report a direct, selective and rapid detection technique of pyocyanin.

MATERIALS & METHODS: Pyocyanin was detected by amperometry at a relatively high potential where the pyocyanin signal was unaffected by background contributions.

RESULTS & CONCLUSION: Pyocyanin was detected at concentrations down to 125 nM in a 50 µM mixture of interfering compounds with a reproducibility of r(2) = 0.999 (n = 5) within 200 s. The results document a step toward a point-of-care technique for diagnosis of P. aeruginosa infections.

Original languageEnglish
JournalNanomedicine (London, England)
Volume11
Issue number16
Pages (from-to)2185-95
Number of pages11
ISSN1743-5889
DOIs
Publication statusPublished - Aug 2016

    Research areas

  • Journal Article

ID: 49928578