Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital

Electrocardiogram Characteristics and Their Association With Psychotropic Drugs Among Patients With Schizophrenia

Research output: Contribution to journalJournal articleResearchpeer-review


  1. Association Between Childhood Green Space, Genetic Liability, and the Incidence of Schizophrenia

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Emotion Recognition and Adverse Childhood Experiences in Individuals at Clinical High Risk of Psychosis

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Identifying Schizo-Obsessive Comorbidity by Tract-Based Spatial Statistics and Probabilistic Tractography

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

Background: There are limited data on electrocardiogram (ECG) characteristics and their association with psychotropic drugs in schizophrenia. Methods: Using a cross-sectional design, we included Danish primary care patients with first-time digital ECGs from 2001 to 2015. Patients diagnosed with schizophrenia before ECG recording were matched 1:5 on age, sex, and ECG recording year to controls without psychiatric disease. Multivariable logistic regression was used to compute odds ratios (ORs) with 95% confidence intervals (CIs). Results: We included 4486 patients with schizophrenia matched with 22 430 controls (median age, 47 years; male, 55%). Between groups, the prevalence of abnormal ECGs was similar (54%, P =. 536), but patients with schizophrenia demonstrated higher median heart rate (79 vs 69 beats per minute, P <. 001) and Fridericia-corrected QT (QTc) interval (416 vs 412 ms, P <. 001) than controls. QTc prolongation was also more prevalent among patients with schizophrenia (3.4% vs 1.1%, P <. 001), and so were pathological Q waves (5.3% vs 3.9%, P <. 001). Patients with schizophrenia less frequently demonstrated left ventricular hypertrophy (6.1% vs 9.6%, P <. 001) and atrial fibrillation or flutter (0.7% vs 1.4%, P <. 001). Among patients with schizophrenia only, particularly antipsychotics were associated with abnormal ECGs (OR, 1.20; 95% CI, 1.04-1.39). Conclusions: Patients with schizophrenia demonstrate a different cardiovascular risk profile than matched controls without psychiatric disease, with higher prevalence of elevated heart rate, QTc prolongation, and pathological Q waves, and lower prevalence of left ventricular hypertrophy and atrial fibrillation or flutter. Particularly antipsychotics were associated with abnormal ECGs. This underscores an integrated care approach when ECG abnormalities are detected in this group.

Original languageEnglish
JournalSchizophrenia Bulletin
Issue number2
Pages (from-to)354-362
Number of pages9
Publication statusPublished - 26 Feb 2020

    Research areas

  • antipsychotics, cardiovascular disease, electrocardiogram, polypharmacy, QT prolongation, schizophrenia

ID: 57549880