Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Efficacy, adverse events, and inter-drug comparison of mepolizumab and reslizumab anti-IL-5 treatments of severe asthma - a systematic review and meta-analysis

Research output: Contribution to journalReviewResearchpeer-review

  1. Clinical characteristics of the BREATHE cohort - a real-life study on patients with asthma and COPD

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Elevated blood eosinophils in acute COPD exacerbations: better short- and long-term prognosis

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Household dampness and microbial exposure related to allergy and respiratory health in Danish adults

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Inspiratory muscle strength and walking capacity in patients with COPD

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Pandemic publishing poses a new COVID-19 challenge

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Reasons for Nonadherence to Statins - A Systematic Review of Reviews

    Research output: Contribution to journalReviewResearchpeer-review

  3. Distinct immune phenotypes in infants developing asthma during childhood

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

Background: New, complex, and expensive therapies targeting Interleukin-5 (IL-5) to treat severe eosinophilic asthma are emerging. Objective: To assess efficacy, adverse events, and inter-drug comparison of mepolizumab and reslizumab for treating severe eosinophilic asthma. Design: A systematic review and meta-analysis on randomized, placebo-controlled, clinical trials elucidating two critical (exacerbation rate and oral corticosteroid (OCS) use) and six important clinical outcomes on the efficacy and safety of mepolizumab and reslizumab. Results: Five studies (N = 2197) contributed with data for exacerbation rate, showing a reduction of 53% (95% CI 46; 59) in favour of anti-IL-5, corresponding to -0.94 annual exacerbations (95% CI -1.08;-0.82), thus exceeding the predefined minimal clinical important difference (MCID) of 25% reduction of the estimated ≥2 annual exacerbations. Quality of evidence was considered moderate, with low heterogeneity in study findings (I2 = 0%). One study (N = 135) contributed with data on percentage of patients experiencing ≥50% reduction inoral corticosteroid treatment, showing an effect of 20% (95% CI 2.3;47) in favour of anti-IL-5 treatment (mepolizumab), thus exceeding the predefined MCID of 10%. Quality of evidence was considered low. Compared to placebo, anti-IL-5 showed significant improvements in lung function, asthma control, and asthma-related quality of life, but below the MCIDs. No differences were observed for serious adverse events and number of patients, who dropped out. No studies evaluating sickleave or head-to-head comparisons were identified. By indirect comparison, we found no significant difference between mepolizumab and reslizumab in any ofthe predefined clinical outcomes. OCS treatment reduction could not be compared due to lack of reslizumab studies investigating this outcome. Conclusions: Mepolizumab and reslizumab provide significant and clinically relevant improvements in exacerbation rate and OCS reduction. Indirect, inter-study comparisons revealed no differences between the anti-IL-5 drugs in efficacy or safety measures.

Original languageEnglish
JournalEuropean Clinical Respiratory Journal
Volume5
Issue number1
Pages (from-to)1536097
ISSN2001-8525
DOIs
Publication statusPublished - 2018

ID: 56349227