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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Effects of unsaturated fat dietary supplements on blood lipids, and on markers of malnutrition and inflammation in hemodialysis patients

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Objective
We examined the effects of commercially available unsaturated fat dietary supplements on blood lipids, and on markers of malnutrition and inflammation, in an adult population of hemodialysis (HD) patients.
Design
This was a restricted, randomized (equal blocks), investigator-blinded 2 × 6 week crossover trial, without a washout interval.
Setting
This study was conducted at the Department of Nephrology, Copenhagen University Hospital Herlev, Herlev, Denmark, in spring 2007.
Patients
Participants included 40 (30 males and 10 females) stable, adult patients undergoing regular HD, with a mean age of 64.6 years and a mean body mass index of 23.3 kg/m2.
Intervention
In addition to patients' habitual diets, oral unsaturated fat supplements (90 mL of Calogen [SHS International, Ltd., Liverpool, UK] and 4 capsules of Pikasol [Dansk Droge, Ishoej, Denmark]) were given in one period, whereas no supplements were given in the other. Dietary supplements contributed 1.8 MJ (430 kcal), 47 g fat, 26.5 g monounsaturated fatty acids, and 3 g marine n-3 polyunsaturated fatty acids per day. Blood sampling and nutritional assessments were performed at baseline, after 6 weeks, and after 12 weeks.
Main Outcome Measures
Dietary intakes, blood lipids, dry body weight, serum albumin, and serum C-reactive protein comprised our main outcome measures.
Results
According to a per-protocol analysis of 14 study completers, fat supplementation resulted in significantly increased total energy intake (+1.6 MJ/day, or 380 kcal/day) and an increased dietary fat energy percentage (+9%). We observed no significant changes in blood lipids. Dry body weight (+0.49 kg, P = .04) increased, and serum C-reactive protein concentration fell (−1.69 mg/L, P = .01), with fat supplementation. Intention-to-treat analysis of 39 participants confirmed the absence of adverse blood-lipid changes.
Conclusions
Unsaturated fat supplementation increased total dietary energy intake to recommended levels, had no adverse impact on blood lipids, improved nutritional status as assessed according to dry body weight, and reduced systemic inflammation as assessed according to C-reactive protein serum concentrations. Adding unsaturated fat to the diet seems to be a safe and effective way to prevent and treat malnutrition in hemodialysis patients.
Original languageEnglish
JournalJournal of Renal Nutrition
Volume19
Issue number5
Pages (from-to)401-11
Number of pages11
ISSN1051-2276
DOIs
Publication statusPublished - Sep 2009

    Research areas

  • Aged, Biomarkers, Body Weight, C-Reactive Protein, Cross-Over Studies, Dietary Fats, Unsaturated, Dietary Supplements, Energy Intake, Fatty Acids, Omega-3, Female, Fish Oils, Humans, Inflammation, Kidney Failure, Chronic, Lipids, Male, Malnutrition, Middle Aged, Nutritional Status, Renal Dialysis, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't

ID: 51962704