Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Effects of one-legged high-intensity interval training on insulin-mediated skeletal muscle glucose homeostasis in patients with type 2 diabetes

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Chromogranin A in cardiovascular endocrinology

    Research output: Contribution to journalEditorialResearchpeer-review

  2. Did you know-why does maximal oxygen uptake increase in humans following endurance exercise training?

    Research output: Contribution to journalEditorialResearchpeer-review

  1. Effects of endogenous GIP in patients with type 2 diabetes

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. The training induced increase in whole-body peak fat oxidation rate may be attenuated with aging

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Mitochondrial dysfunction in adults after out-of-hospital cardiac arrest

    Research output: Contribution to journalJournal articleResearchpeer-review

  • Flemming Dela
  • Arthur Ingersen
  • Nynne B Andersen
  • Maria B Nielsen
  • Helga H H Petersen
  • Christina N Hansen
  • Steen Larsen
  • Jørgen Wojtaszewski
  • Jørn Wulff Helge
View graph of relations

AIM: To examine the effect of high-intensity interval training (HIIT) on glucose clearance rates in skeletal muscle and explore the mechanism within the muscle.

METHODS: Ten males with type 2 diabetes mellitus (T2DM) and ten matched healthy subjects performed 2 weeks of one-legged HIIT (total of eight sessions, each comprised of 10 × 1 minute ergometer bicycle exercise at >80% of maximal heart rate, interspersed with one min of rest). Insulin sensitivity was assessed by an isoglycaemic, hyperinsulinaemic clamp combined with arteriovenous leg balance technique of the trained (T) and the untrained (UT) leg and muscle biopsies of both legs.

RESULTS: Insulin-stimulated glucose clearance in T legs was ~30% higher compared with UT legs in both groups due to increased blood flow in T vs UT legs and maintained glucose extraction. With each training session, muscle glycogen content decreased only in the training leg, and after the training, glycogen synthase and citrate synthase activities were higher in T vs UT legs. No major changes occurred in the expression of proteins in the insulin signalling cascade. Mitochondrial respiratory capacity was similar in T2DM and healthy subjects, and unchanged by HIIT.

CONCLUSION: HIIT improves skeletal muscle insulin sensitivity. With HIIT, the skeletal muscle of patients with T2DM becomes just as insulin sensitive as untrained muscle in healthy subjects. The mechanism includes oscillations in muscle glycogen stores and a maintained ability to extract glucose from the blood in the face of increased blood flow in the trained leg.

Original languageEnglish
JournalActa Physiologica
Volume226
Issue number2
Pages (from-to)e13245
ISSN1748-1708
DOIs
Publication statusPublished - Jun 2019

ID: 59397148