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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Effects of nutrient intake on sympathoadrenal activity and thermogenic mechanisms

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  1. Validation of a new data-driven automated algorithm for muscular activity detection in REM sleep behavior disorder

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  2. Automatic delineation of brain regions on MRI and PET images from the pig

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  3. Comparison of Analytical Methods of Brain [(18)F]FDG-PET after Severe Traumatic Brain Injury

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  4. Subjective perception of cocaine reward in mice assessed by a single exposure place preference (sePP) paradigm

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  5. Nerve excitability in the rat forelimb: a technique to improve translational utility

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  1. Increased oral sodium chloride intake in humans amplifies selectively postprandial GLP-1 but not GIP, CCK, and gastrin in plasma

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  2. The Copenhagen Sarcopenia Study: lean mass, strength, power, and physical function in a Danish cohort aged 20-93 years

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  3. Abdominal fat distribution measured by ultrasound and aerobic fitness in young Danish men born with low and normal birth weight

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Ingestion of carbohydrate results in a diphasic activation of the sympathoadrenal system. One component is an insulin-mediated activation of the sympathetic nervous system (SNS). This activation is partly a haemodynamic reflex, but it may cause a weak thermogenic effect via beta 1-adrenoceptors in white adipose tissue, the liver and the heart. The second thermogenic component of carbohydrate occurs later when the blood glucose concentration decreases towards baseline levels. This elicits an increased secretion of adrenaline from the adrenal medulla, and the circulating level exceeds the physiological threshold for thermogenic effect. The target is mainly skeletal muscle where thermogenesis is stimulated via beta 2-adrenoceptors. Also the basal metabolic rate and the thermogenic responses to cold and heat exposure, mental stress and exercise, have facultative components. Inhibition of facultative thermogenesis by beta-blockers such as propranolol, diminishes the daily energy expenditure and promotes weight gain and obesity. Although thermogenesis mediated by the sympathoadrenal system accounts for only a small part of the daily energy expenditure, it is sufficient to explain the positive energy balance and weight gain reported in patients receiving treatment with beta-adrenoceptor blocking agents.
Original languageEnglish
JournalJournal of Neuroscience Methods
Volume34
Issue number1-3
Pages (from-to)187-92
Number of pages6
ISSN0165-0270
Publication statusPublished - Sep 1990

    Research areas

  • Adrenal Glands, Animal Nutritional Physiological Phenomena, Animals, Body Temperature Regulation, Humans, Nutritional Physiological Phenomena, Sympathetic Nervous System

ID: 39023600