Effects of mutations in Pneumocystis carinii dihydropteroate synthase gene on outcome of AIDS-associated P. carinii pneumonia

J Helweg-Larsen; Thomas Benfield; J Eugen-Olsen; J D Lundgren; B Lundgren

doi:10.1016/S0140-6736(99)03320-6

Effects of mutations in Pneumocystis carinii dihydropteroate synthase gene on outcome of AIDS-associated P. carinii pneumonia

J Helweg-Larsen, Thomas Benfield, J Eugen-Olsen, J D Lundgren, B Lundgren

249 Citations (Scopus)

Abstract

Sulpha drugs are widely used for the treatment and long-term prophylaxis of Pneumocystis carinii pneumonia (PCP) in HIV-1-infected individuals. Sulpha resistance in many microorganisms is caused by point mutations in dihydropteroate synthase (DHPS), an enzyme that is essential for folate biosynthesis. We assessed whether mutations in the DHPS gene of P. carinii were associated with exposure to sulpha drugs and influenced outcome from PCP.

Original language	English
Journal	Lancet
Volume	354
Issue number	9187
Pages (from-to)	1347-51
Number of pages	5
ISSN	0140-6736
DOIs	https://doi.org/10.1016/S0140-6736(99)03320-6
Publication status	Published - 1999

Keywords

AIDS-Related Opportunistic Infections
Adult
Aged
Bronchoalveolar Lavage Fluid
Cohort Studies
Dihydropteroate Synthase
Drug Resistance, Microbial
Genotype
HIV-1
Humans
Middle Aged
Pneumocystis
Pneumonia, Pneumocystis
Point Mutation
Polymerase Chain Reaction
Prognosis
Recurrence
Regression Analysis
Sulfamethoxazole
Survival Analysis

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10.1016/S0140-6736(99)03320-6

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title = "Effects of mutations in Pneumocystis carinii dihydropteroate synthase gene on outcome of AIDS-associated P. carinii pneumonia",

abstract = "Sulpha drugs are widely used for the treatment and long-term prophylaxis of Pneumocystis carinii pneumonia (PCP) in HIV-1-infected individuals. Sulpha resistance in many microorganisms is caused by point mutations in dihydropteroate synthase (DHPS), an enzyme that is essential for folate biosynthesis. We assessed whether mutations in the DHPS gene of P. carinii were associated with exposure to sulpha drugs and influenced outcome from PCP.",

keywords = "AIDS-Related Opportunistic Infections, Adult, Aged, Bronchoalveolar Lavage Fluid, Cohort Studies, Dihydropteroate Synthase, Drug Resistance, Microbial, Genotype, HIV-1, Humans, Middle Aged, Pneumocystis, Pneumonia, Pneumocystis, Point Mutation, Polymerase Chain Reaction, Prognosis, Recurrence, Regression Analysis, Sulfamethoxazole, Survival Analysis",

author = "J Helweg-Larsen and Thomas Benfield and J Eugen-Olsen and Lundgren, \{J D\} and B Lundgren",

year = "1999",

doi = "10.1016/S0140-6736(99)03320-6",

language = "English",

volume = "354",

pages = "1347--51",

journal = "Lancet",

issn = "0140-6736",

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TY - JOUR

T1 - Effects of mutations in Pneumocystis carinii dihydropteroate synthase gene on outcome of AIDS-associated P. carinii pneumonia

AU - Helweg-Larsen, J

AU - Benfield, Thomas

AU - Eugen-Olsen, J

AU - Lundgren, J D

AU - Lundgren, B

PY - 1999

Y1 - 1999

N2 - Sulpha drugs are widely used for the treatment and long-term prophylaxis of Pneumocystis carinii pneumonia (PCP) in HIV-1-infected individuals. Sulpha resistance in many microorganisms is caused by point mutations in dihydropteroate synthase (DHPS), an enzyme that is essential for folate biosynthesis. We assessed whether mutations in the DHPS gene of P. carinii were associated with exposure to sulpha drugs and influenced outcome from PCP.

AB - Sulpha drugs are widely used for the treatment and long-term prophylaxis of Pneumocystis carinii pneumonia (PCP) in HIV-1-infected individuals. Sulpha resistance in many microorganisms is caused by point mutations in dihydropteroate synthase (DHPS), an enzyme that is essential for folate biosynthesis. We assessed whether mutations in the DHPS gene of P. carinii were associated with exposure to sulpha drugs and influenced outcome from PCP.

KW - AIDS-Related Opportunistic Infections

KW - Adult

KW - Aged

KW - Bronchoalveolar Lavage Fluid

KW - Cohort Studies

KW - Dihydropteroate Synthase

KW - Drug Resistance, Microbial

KW - Genotype

KW - HIV-1

KW - Humans

KW - Middle Aged

KW - Pneumocystis

KW - Pneumonia, Pneumocystis

KW - Point Mutation

KW - Polymerase Chain Reaction

KW - Prognosis

KW - Recurrence

KW - Regression Analysis

KW - Sulfamethoxazole

KW - Survival Analysis

UR - https://www.scopus.com/pages/publications/0033576172

U2 - 10.1016/S0140-6736(99)03320-6

DO - 10.1016/S0140-6736(99)03320-6

M3 - Journal article

C2 - 10533864

SN - 0140-6736

VL - 354

SP - 1347

EP - 1351

JO - Lancet

JF - Lancet

IS - 9187

ER -

Effects of mutations in Pneumocystis carinii dihydropteroate synthase gene on outcome of AIDS-associated P. carinii pneumonia

Abstract

Keywords

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