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Effects of liraglutide on ovarian dysfunction in polycystic ovary syndrome: a randomized clinical trial

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  1. Meditation and mindfulness reduce perceived stress in women with recurrent pregnancy loss: a randomized controlled trial

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  2. Stress and depression among women and men who have experienced recurrent pregnancy loss: focusing on both sexes

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  3. Empathetic application of machine learning may address appropriate utilization of ART

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  4. Futures and fears in the freezer: Danish women's experiences with ovarian tissue cryopreservation and transplantation

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  5. The reproductive microbiome - clinical practice recommendations for fertility specialists

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  1. Effect of Anabolic-Androgenic Steroid Abuse on the Contact Activation System

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  2. Effects of Empagliflozin on Myocardial Flow Reserve in Patients With Type 2 Diabetes Mellitus: The SIMPLE Trial

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  3. Mineralocorticoid receptor antagonist improves cardiac structure in Type 2 Diabetes: Data from the MIRAD Trial

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  4. Acute hypoglycemia and risk of cardiac arrhythmias in insulin-treated type 2 diabetes and controls

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Polycystic ovary syndrome (PCOS) encompasses an ovarian and a metabolic dysfunction. Glucagon-like peptide-1 (GLP-1) analogues facilitate weight loss and ameliorate metabolic dysfunction in overweight women with PCOS, but their effect on ovarian dysfunction is scarcely reported. In a double-blind, randomized trial, 72 women with PCOS were allocated to intervention with the GLP-1 analogue liraglutide or placebo (1.8 mg/day), in a 2:1 ratio. At baseline and 26-week follow-up, bleeding pattern, levels of AMH, sex hormones and gonadotrophins were assessed and ovarian morphology evaluated. Liraglutide caused 5.2 kg (95% CI 3.0 to 7.5, P < 0.0001) weight loss compared with placebo. Bleeding ratio improved with liraglutide: 0.28 (95% CI 0.20 to 0.36, P < 0.001); placebo: 0.14 (95% CI 0.02 to 0.26, P < 0.05); between-group difference: 0.14 (95% CI 0.03 to 0.24, P < 0.05). In the liraglutide group, SHBG increased by 7.4 nmol/L (95% CI 4.1 to 10.7) and free testosterone decreased by 0.005 nmol/L (95% CI -0.009 to -0.001). Ovarian volume decreased by -1.6 ml (95% CI -3.3 to 0.1) with liraglutide versus placebo. Nausea and constipation were more prevalent in the liraglutide group. Liraglutide improved markers of ovarian function in overweight women with PCOS, and might be a possible intervention.

Original languageEnglish
JournalReproductive BioMedicine Online
Volume35
Issue number1
Pages (from-to)121-127
Number of pages7
ISSN1472-6483
DOIs
Publication statusPublished - Jul 2017

    Research areas

  • Journal Article

ID: 52541541