Effects of gastric bypass surgery on glucose absorption and metabolism during a mixed meal in glucose-tolerant individuals

Siv H Jacobsen, Kirstine N Bojsen-Møller, Carsten Dirksen, Nils B Jørgensen, Trine R Clausen, Birgitte S Wulff, Viggo B Kristiansen, Dorte Worm, Dorte L Hansen, Jens Juul Holst, Gerrit van Hall, Sten Madsbad

99 Citations (Scopus)

Abstract

Roux-en-Y gastric bypass surgery (RYGB) improves glucose tolerance in patients with type 2 diabetes, but also changes the glucose profile in response to a meal in glucose-tolerant individuals. We hypothesised that the driving force for the changed postprandial glucose profiles after RYGB is rapid entry of glucose into the systemic circulation due to modified gastrointestinal anatomy, causing hypersecretion of insulin and other hormones influencing glucose disappearance and endogenous glucose production.
Original languageEnglish
JournalDiabetologia
Volume56
Issue number10
Pages (from-to)2250-4
Number of pages5
ISSN0012-186X
DOIs
Publication statusPublished - Oct 2013

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