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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Effects of erythropoietin on memory-relevant neurocircuitry activity and recall in mood disorders

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  5. Meta-analysis of antidepressant effects of anti-inflammatory drugs-reply

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  1. Functional hypoxia drives neuroplasticity and neurogenesis via brain erythropoietin

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  2. Blood pressure and brain injury in cardiac surgery: a secondary analysis of a randomized trial

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  3. Blocking of efflux transporters in rats improves translational validation of brain radioligands

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  4. Cerebellar - premotor cortex interactions underlying visuomotor adaptation

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OBJECTIVE: Erythropoietin (EPO) improves verbal memory and reverses subfield hippocampal volume loss across depression and bipolar disorder (BD). This study aimed to investigate with functional magnetic resonance imaging (fMRI) whether these effects were accompanied by functional changes in memory-relevant neuro-circuits in this cohort.

METHOD: Eighty-four patients with treatment-resistant unipolar depression who were moderately depressed or BD in remission were randomized to eight weekly EPO (40 000 IU) or saline infusions in a double-blind, parallel-group design. Participants underwent whole-brain fMRI at 3T, mood ratings, and blood tests at baseline and week 14. During fMRI, participants performed a picture encoding task followed by postscan recall.

RESULTS: Sixty-two patients had complete data (EPO: N = 32, saline: N = 30). EPO improved picture recall and increased encoding-related activity in dorsolateral prefrontal cortex (dlPFC) and temporo-parietal regions, but not in hippocampus. Recall correlated with activity in the identified dlPFC and temporo-parietal regions at baseline, and change in recall correlated with activity change in these regions from baseline to follow-up across the entire cohort. The effects of EPO were not correlated with change in mood, red blood cells, blood pressure, or medication.

CONCLUSION: The findings highlight enhanced encoding-related dlPFC and temporo-parietal activity as key neuronal underpinnings of EPO-associated memory improvement.

Original languageEnglish
JournalActa Psychiatrica Scandinavica
Volume134
Issue number3
Pages (from-to)249-59
Number of pages11
ISSN0001-690X
DOIs
Publication statusPublished - Sep 2016

    Research areas

  • Journal Article

ID: 48422702