Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Effects of erythropoietin on emotional processing biases in patients with major depression: an exploratory fMRI study

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Correction to: Effects of glucagon-like peptide 1 analogs on alcohol intake in alcohol-preferring vervet monkeys

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Three weeks of SSRI administration enhances the visual perceptual threshold - a randomized placebo-controlled study

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Tryptophan depletion affects compulsive behaviour in rats: strain dependent effects and associated neuromechanisms

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. The effect of erythropoietin on electroconvulsive stimulation induced cognitive impairment in rats

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Trajectory of cognitive functions in bipolar disorder: for better or worse?

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Characteristics influencing expected cognitive performance during hypoglycaemia in type 2 diabetes

    Research output: Contribution to journalJournal articleResearchpeer-review

  • Kamilla W Miskowiak
  • Elisa Favaron
  • Sepehr Hafizi
  • Becky Inkster
  • Guy M Goodwin
  • Philip J Cowen
  • Catherine J Harmer
View graph of relations
INTRODUCTION: Erythropoietin (Epo) has neurotrophic effects and may be a novel therapeutic agent in the treatment of depression. We have found antidepressant-like effects of Epo on emotional processing and mood in healthy volunteers. OBJECTIVE: The current study aimed to explore the effects of Epo on the neural processing of emotional information in depressed patients. MATERIALS AND METHODS: Seventeen patients with acute major depressive disorder were randomised to receive Epo (40,000 IU) or saline iv in a double-blind, parallel-group design. On day 3, we assessed neural responses to positive, negative and neutral pictures during fMRI followed by picture recall after the scan. Mood and blood parameters were assessed at baseline and on day 3. RESULTS: Epo reduced neural response to negative vs. positive pictures 3 days post-administration in a network of areas including the hippocampus, ventromedial prefrontal and parietal cortex. After the scan, Epo-treated patients showed improved memory compared with those that were given placebo. The effects occurred in the absence of changes in mood or haematological parameters, suggesting that they originated from direct neurobiological actions of Epo. CONCLUSIONS: These findings are similar to the effects of conventional antidepressants and opposite to the negative biases in depression. The central effects of Epo therefore deserve further investigation as a potential antidepressant mechanism.
Original languageEnglish
JournalPsychopharmacology
Volume207
Issue number1
Pages (from-to)133-42
Number of pages9
DOIs
Publication statusPublished - 2009

Bibliographical note

Keywords: Adult; Antidepressive Agents; Bias (Epidemiology); Brain; Brain Mapping; Depressive Disorder, Major; Double-Blind Method; Emotions; Erythropoietin; Facial Expression; Female; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Male; Middle Aged; Oxygen; Photic Stimulation; Reaction Time; Recognition (Psychology); Time Factors; Young Adult

ID: 170964