Effects of endotoxaemia on markers of permeability, metabolism and inflammation in the large bowel of healthy subjects

V L Jørgensen, M Ibsen, L Andresen, J D Schulzke, A Perner

    11 Citations (Scopus)

    Abstract

    Increased permeability and increased luminal concentrations of L-lactate have previously been shown in the large bowel in septic patients. To advance these observations, a human model of colorectal barrier failure in sepsis is desirable. Therefore, we assessed the effects of endotoxaemia on markers of permeability, metabolism and inflammation in the large bowel in healthy subjects.
    Original languageEnglish
    JournalActa Anaesthesiologica Scandinavica
    Volume51
    Issue number8
    Pages (from-to)1085-92
    Number of pages8
    ISSN0001-5172
    DOIs
    Publication statusPublished - Sept 2007

    Keywords

    • Adult
    • Apoptosis
    • Biological Markers
    • Cross-Over Studies
    • Endotoxemia
    • Endotoxins
    • Humans
    • Inflammation
    • Intestinal Absorption
    • Lactic Acid
    • Male
    • Nitric Oxide Synthase Type II
    • Protein C
    • Rectum
    • Tumor Necrosis Factors

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