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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Effects of an exercise intervention for patients with advanced inoperable lung cancer undergoing chemotherapy: A randomized clinical trial

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  1. Characteristics of 252 patients with bronchopulmonary neuroendocrine tumours treated at the Copenhagen NET Centre of Excellence

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  2. Treatment, no treatment and early death in Danish stage I lung cancer patients

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Patient reported outcome data as performance indicators in surgically treated lung cancer patients

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OBJECTIVE: Exercise can improve treatment-related side effects, quality of life, and function in patients with various types of cancer; however, more evidence is needed for patients with advanced inoperable lung cancer.

MATERIAL AND METHODS: We randomized 218 patients with advanced inoperable lung cancer to a 12-week supervised, structured exercise training program (aerobic, strength, and relaxation training) twice weekly versus usual care. Primary outcome was change in maximal oxygen uptake (VO2 peak). Secondary outcomes were muscle strength, functional capacity, forced expiratory volume in 1 s, health-related quality of life, anxiety, and depression.

RESULTS: There was no significant difference between the intervention and control groups in VO2 peak. There was a significant improvement in muscle strength. There was also a significant difference between the two for social well-being (Functional Assessment of Cancer Therapy-Lung, FACT-L), anxiety, and depression.

CONCLUSION: There was a significant reduction in the level of anxiety and depression and a significant increase in all muscle strength outcomes in the intervention group compared to patients randomized to usual care. There was a significant difference between the groups for social well-being. The primary outcome did not show a significant improvement in VO2 peak. Based on our results, future patients with advanced inoperable lung cancer should be considered for supervised exercise during the course of their disease.

Original languageEnglish
JournalLung Cancer
Volume145
Pages (from-to)76-82
Number of pages7
ISSN0169-5002
DOIs
Publication statusPublished - Jul 2020

    Research areas

  • Advanced stage, Exercise, Lung cancer, Palliation

ID: 59857327