Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Effects of active commuting and leisure-time exercise on appetite in individuals with overweight and obesity

Research output: Contribution to journalJournal articleResearchpeer-review

  1. The influence of direct and indirect fibroblast cell contact on human myogenic cell behavior and gene expression in vitro

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Mechanical properties, physiological behavior, and function of aponeurosis and tendon

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Plasma Free Fatty Acid concentration is closely tied to whole-body peak fat oxidation rate during repeated exercise

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Integrated method for quantitative morphometry and oxygen transport modeling in striated muscle

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Oral D/L-3-Hydroxybutyrate stimulates cholecystokinin and insulin secretion and slows gastric emptying in healthy males

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Bilio-enteric flow and plasma concentrations of bile acids after gastric bypass and sleeve gastrectomy

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Circadian variations in plasma concentrations of cholecystokinin and gastrin in man

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Increased oral sodium chloride intake in humans amplifies selectively postprandial GLP-1 but not GIP, CCK, and gastrin in plasma

    Research output: Contribution to journalJournal articleResearchpeer-review

  • Jonas Salling Quist
  • Martin Bæk Blond
  • Anne Sofie Gram
  • Carina Bjørnskov Steenholt
  • Charlotte Janus
  • Jens Juul Holst
  • Jens F Rehfeld
  • Anders Sjödin
  • Bente Stallknecht
  • Mads Rosenkilde
View graph of relations

Acute exercise is associated with a transient suppression of appetite. The effects of regular exercise on appetite are not well understood. We aimed to determine the effects of active commuting and leisure-time exercise on appetite. One hundred thirty physically inactive women and men (20-45 yr) with overweight and obesity were randomized to 6 mo of habitual lifestyle (CON, n = 18), active commuting (BIKE, n = 35), or leisure-time exercise of moderate [MOD, 50% peak oxygen uptake (V̇o2peak)-reserve, n = 39] or vigorous (VIG, 70% V̇o2peak-reserve, n = 38) intensity. Appetite ratings, acylated ghrelin, cholecystokinin (CCK), glucagon-like peptide-1 (GLP-1), peptide YY (PYY), and glucagon were assessed in the basal state and in response to meal and exercise challenges at baseline and 3 and 6 mo. Ad libitum energy intake was determined during test meals. Data from 90 participants (per protocol) were available, and results are comparisons with CON. At 3 mo, ad libitum energy intake was lower in VIG (-22%, P < 0.01), basal glucagon was lower in BIKE ( P < 0.05) and VIG ( P = 0.01), and postprandial ratings of prospective food consumption were lower in MOD ( P = 0.02) and VIG ( P < 0.001). In VIG, ratings of hunger ( P = 0.01) and prospective food consumption ( P = 0.03) were lower after acute exercise at 3 mo. At 6 mo, basal and postprandial GLP-1 were higher ( P ≤ 0.04) whereas postexercise PYY was lower ( P = 0.03) in VIG and postexercise CCK was lower in BIKE ( P = 0.03). Vigorous-intensity exercise training leads to a transient suppression of energy intake and subjective appetite (3 mo) but a more long-term increase in basal and postprandial GLP-1 (6 mo) in individuals with overweight and obesity. NEW & NOTEWORTHY This is the first randomized controlled trial, to our knowledge, investigating long-term effects of exercise domain and intensity on subjective and hormonal markers of appetite and ad libitum energy intake in individuals with overweight and obesity. Appetite was assessed in response to meal and exercise challenges at baseline and at 3 and 6 mo. Anorexigenic effects of exercise vary with the duration of intervention and are restricted to regular leisure-time exercise of vigorous intensity in individuals with overweight and obesity.

Original languageEnglish
JournalJournal of Applied Physiology
Volume126
Issue number4
Pages (from-to)941-951
Number of pages11
ISSN0161-7567
DOIs
Publication statusPublished - 1 Apr 2019

ID: 57231148