Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Effects of a Lifestyle Intervention on Bone Turnover in Persons with Type 2 Diabetes: A post hoc Analysis of the U-TURN Trial

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Hepcidin and Erythroferrone Complement the Athlete Biological Passport in the Detection of Autologous Blood Transfusion

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Threshold of Relative Muscle Power Required to Rise from a Chair and Mobility Limitations and Disability in Older Adults

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Altered Triceps Surae Muscle-Tendon Unit Properties after 6 Months of Static Stretching

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. An Untargeted Urine Metabolomics Approach for Autologous Blood Transfusion Detection

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Exercise suppresses tumor growth independent of high fat food intake and associated immune dysfunction

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Reply to 'Lactate as a major myokine and exerkine'

    Research output: Contribution to journalLetterResearchpeer-review

  3. Human visceral and subcutaneous adipose stem and progenitor cells retain depot-specific adipogenic properties during obesity

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

INTRODUCTION/PURPOSE: The increased risk of fractures with type 2 diabetes (T2D) is suggested to be caused by decreased bone turnover. Current international guidelines recommend lifestyle modifications, including exercise, as first-line treatment for T2D. The aim of this study was to investigate the effects of an exercise-based lifestyle intervention on bone turnover and bone mineral density (BMD) in persons with T2D.

METHODS: Persons with T2D were randomized to either a 12-month lifestyle intervention (n = 64) or standard care (n = 34). The lifestyle intervention included five to six weekly aerobic training sessions, half of them combined with resistance training. Serum markers of bone turnover (osteocalcin, N-terminal propeptide of type-I procollagen, reflecting bone formation, and carboxyterminal collagen I crosslinks, reflecting bone resorption) and BMD (by DXA) were measured before the intervention and at follow-up.

RESULTS: From baseline to follow-up, s-propeptide of type-I procollagen increased by 34% (95% confidence interval [CI], 17%-50%), serum-carboxyterminal collagen I crosslink by 36% (95% CI, 1%-71%), and s-osteocalcin by 31% (95% CI, 11-51%) more in the lifestyle intervention group compared with standard care. Loss of weight and fat mass were the strongest mediators of the increased bone turnover. Bone mineral density was unaffected by the intervention (ΔBMD, 0.1%; 95% CI, -1.1% to 1.2%).

CONCLUSIONS: A 12-month intensive exercise-based lifestyle intervention led to a substantial but balanced increase in bone turnover in persons with T2D. The increased bone turnover combined with a preserved BMD, despite a considerable weight loss, is likely to reflect improved bone health and warrants further studies addressing the impact of exercise on risk of fractures in persons with T2D.

Original languageEnglish
JournalMedicine and Science in Sports and Exercise
Volume54
Issue number1
Pages (from-to)38-46
Number of pages9
ISSN0195-9131
DOIs
Publication statusPublished - 1 Jan 2022

ID: 67569108