Effectiveness of treatment with pegylated interferon and ribavirin in an unselected population of patients with chronic hepatitis C: a Danish nationwide cohort study

Nanna Hansen; Niels Obel; Peer Christensen; Mette Skalshøi Kjær; Alex Lund Laursen; Henrik Bygum Krarup; Axel Møller; Poul Schlichting; Jens Bukh; Nina Margrethe Weis; Danish Database for Hepatitis B and C (DANHEP)- group; Peter Nørregaard; Suzanne Lunding

doi:10.1186/1471-2334-11-177

Effectiveness of treatment with pegylated interferon and ribavirin in an unselected population of patients with chronic hepatitis C: a Danish nationwide cohort study

Nanna Hansen, Niels Obel, Peer Christensen, Mette Skalshøi Kjær, Alex Lund Laursen, Henrik Bygum Krarup, Axel Møller, Poul Schlichting, Jens Bukh, Nina Margrethe Weis, Danish Database for Hepatitis B and C (DANHEP)- group, Peter Nørregaard, Suzanne Lunding

22 Citations (Scopus)

Abstract

The effect of peginterferon and ribavirin treatment on chronic hepatitis C virus (HCV) infection has been established in several controlled clinical studies. However, the effectiveness of treatment and predictors of treatment success in routine clinical practice remains to be established. Our aim was to estimate the effectiveness of peginterferon and ribavirin treatment in unselected HCV patients handled in routine clinical practice. The endpoint was sustained virological response (SVR), determined by the absence of HCV RNA 24 weeks after the end of treatment.

Original language	English
Journal	B M C Infectious Diseases
Volume	11
Pages (from-to)	177
ISSN	1471-2334
DOIs	https://doi.org/10.1186/1471-2334-11-177
Publication status	Published - 1 Jan 2011

Keywords

Adult
Aged
Antiviral Agents
Cohort Studies
Denmark
Female
Hepacivirus
Hepatitis C, Chronic
Humans
Interferon Alfa-2a
Logistic Models
Male
Middle Aged
Polyethylene Glycols
RNA, Viral
Ribavirin
Treatment Outcome

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Hansen, N., Obel, N., Christensen, P., Kjær, M. S., Laursen, A. L., Krarup, H. B., Møller, A., Schlichting, P., Bukh, J., Weis, N. M., Danish Database for Hepatitis B and C (DANHEP)- group, Nørregaard, P., & Lunding, S. (2011). Effectiveness of treatment with pegylated interferon and ribavirin in an unselected population of patients with chronic hepatitis C: a Danish nationwide cohort study. B M C Infectious Diseases, 11, 177. https://doi.org/10.1186/1471-2334-11-177

Effectiveness of treatment with pegylated interferon and ribavirin in an unselected population of patients with chronic hepatitis C: a Danish nationwide cohort study. / Hansen, Nanna; Obel, Niels; Christensen, Peer et al.
In: B M C Infectious Diseases, Vol. 11, 01.01.2011, p. 177.

Research output: Contribution to journal › Journal article › Research › peer-review

Hansen, N, Obel, N, Christensen, P, Kjær, MS, Laursen, AL, Krarup, HB, Møller, A, Schlichting, P, Bukh, J , Weis, NM, Danish Database for Hepatitis B and C (DANHEP)- group, Nørregaard, P & Lunding, S 2011, 'Effectiveness of treatment with pegylated interferon and ribavirin in an unselected population of patients with chronic hepatitis C: a Danish nationwide cohort study', B M C Infectious Diseases, vol. 11, pp. 177. https://doi.org/10.1186/1471-2334-11-177

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abstract = "The effect of peginterferon and ribavirin treatment on chronic hepatitis C virus (HCV) infection has been established in several controlled clinical studies. However, the effectiveness of treatment and predictors of treatment success in routine clinical practice remains to be established. Our aim was to estimate the effectiveness of peginterferon and ribavirin treatment in unselected HCV patients handled in routine clinical practice. The endpoint was sustained virological response (SVR), determined by the absence of HCV RNA 24 weeks after the end of treatment.",

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AU - Kjær, Mette Skalshøi

AU - Laursen, Alex Lund

AU - Krarup, Henrik Bygum

AU - Møller, Axel

AU - Schlichting, Poul

AU - Bukh, Jens

AU - Weis, Nina Margrethe

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AU - Nørregaard, Peter

AU - Lunding, Suzanne

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AB - The effect of peginterferon and ribavirin treatment on chronic hepatitis C virus (HCV) infection has been established in several controlled clinical studies. However, the effectiveness of treatment and predictors of treatment success in routine clinical practice remains to be established. Our aim was to estimate the effectiveness of peginterferon and ribavirin treatment in unselected HCV patients handled in routine clinical practice. The endpoint was sustained virological response (SVR), determined by the absence of HCV RNA 24 weeks after the end of treatment.

KW - Adult

KW - Aged

KW - Antiviral Agents

KW - Cohort Studies

KW - Denmark

KW - Female

KW - Hepacivirus

KW - Hepatitis C, Chronic

KW - Humans

KW - Interferon Alfa-2a

KW - Logistic Models

KW - Male

KW - Middle Aged

KW - Polyethylene Glycols

KW - RNA, Viral

KW - Ribavirin

KW - Treatment Outcome

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JO - B M C Infectious Diseases

JF - B M C Infectious Diseases

ER -

Effectiveness of treatment with pegylated interferon and ribavirin in an unselected population of patients with chronic hepatitis C: a Danish nationwide cohort study

Abstract

Keywords

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