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Effectiveness of nutritional interventions in older adults at risk of malnutrition across different health care settings: Pooled analyses of individual participant data from nine randomized controlled trials

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Harvard

Reinders, I, Volkert, D, de Groot, LCPGM, Beck, AM, Feldblum, I, Jobse, I, Neelemaat, F, de van der Schueren, MAE, Shahar, DR, Smeets, ETHC, Tieland, M, Twisk, JWR, Wijnhoven, HAH & Visser, M 2019, 'Effectiveness of nutritional interventions in older adults at risk of malnutrition across different health care settings: Pooled analyses of individual participant data from nine randomized controlled trials', Clinical Nutrition, vol. 38, no. 4, 4, pp. 1797-1806. https://doi.org/10.1016/j.clnu.2018.07.023

APA

Reinders, I., Volkert, D., de Groot, L. C. P. G. M., Beck, A. M., Feldblum, I., Jobse, I., Neelemaat, F., de van der Schueren, M. A. E., Shahar, D. R., Smeets, E. T. H. C., Tieland, M., Twisk, J. W. R., Wijnhoven, H. A. H., & Visser, M. (2019). Effectiveness of nutritional interventions in older adults at risk of malnutrition across different health care settings: Pooled analyses of individual participant data from nine randomized controlled trials. Clinical Nutrition, 38(4), 1797-1806. [4]. https://doi.org/10.1016/j.clnu.2018.07.023

CBE

Reinders I, Volkert D, de Groot LCPGM, Beck AM, Feldblum I, Jobse I, Neelemaat F, de van der Schueren MAE, Shahar DR, Smeets ETHC, Tieland M, Twisk JWR, Wijnhoven HAH, Visser M. 2019. Effectiveness of nutritional interventions in older adults at risk of malnutrition across different health care settings: Pooled analyses of individual participant data from nine randomized controlled trials. Clinical Nutrition. 38(4):1797-1806. https://doi.org/10.1016/j.clnu.2018.07.023

MLA

Vancouver

Author

Reinders, Ilse ; Volkert, Dorothee ; de Groot, Lisette C P G M ; Beck, Anne Marie ; Feldblum, Ilana ; Jobse, Inken ; Neelemaat, Floor ; de van der Schueren, Marian A.E. ; Shahar, Danit R. ; Smeets, Ellen T.H.C. ; Tieland, Michael ; Twisk, Jos W R ; Wijnhoven, Hanneke A.H. ; Visser, Marjolein. / Effectiveness of nutritional interventions in older adults at risk of malnutrition across different health care settings: Pooled analyses of individual participant data from nine randomized controlled trials. In: Clinical Nutrition. 2019 ; Vol. 38, No. 4. pp. 1797-1806.

Bibtex

@article{7db106a463154184a6c8c1acd3a32ea9,
title = "Effectiveness of nutritional interventions in older adults at risk of malnutrition across different health care settings: Pooled analyses of individual participant data from nine randomized controlled trials",
abstract = "Background & aims Protein-energy malnutrition is a health concern among older adults. Improving nutritional status by increasing energy and protein intake likely benefits health. We therefore aimed to investigate effects of nutritional interventions in older adults (at risk of malnutrition) on change in energy intake and body weight, and explore if the intervention effect was modified by study or participants{\textquoteright} characteristics, analysing pooled individual participant data. Methods We searched for RCTs investigating the effect of dietary counseling, oral nutritional supplements (ONS) or both on energy intake and weight. Principle investigators of eligible studies provided individual participant data. We investigated the effect of nutritional intervention on meaningful increase in energy intake (>250 kcal/day) and meaningful weight gain (>1.0 kg). Logistic generalized estimating equations were performed and ORs with 95% CIs presented. Results We included data of nine studies with a total of 990 participants, aged 79.2 ± 8.2 years, 64.5% women and mean baseline BMI 23.9 ± 4.7 kg/m2. An non-significant intervention effect was observed for increase in energy intake (OR:1.59; 95% CI 0.95, 2.66) and a significant intervention effect for weight gain (OR:1.58; 95% CI 1.16, 2.17). Stratifying by type of intervention, an intervention effect on increase in energy intake was only observed for dietary counseling in combination with ONS (OR:2.28; 95% CI 1.90, 2.73). The intervention effect on increase in energy intake was greater for women, older participants, and those with lower BMI. Regarding weight gain, an intervention effect was observed for dietary counseling (OR:1.40; 95% CI 1.14, 1.73) and dietary counseling in combination with ONS (OR:2.48; 95% CI 1.92, 3.31). The intervention effect on weight gain was not influenced by participants{\textquoteright} characteristics. Conclusions Based on pooled data of older adults (at risk of malnutrition), nutritional interventions have a positive effect on energy intake and body weight. Dietary counseling combined with ONS is the most effective intervention.",
keywords = "Health Sciences, Dietary counseling, Oral nutritional supplements, Protein-energy malnutrition, Undernutrition, Weight gain, Dietary counseling, Oral nutritional supplements, Protein-energy malnutrition, Undernutrition, Weight gain",
author = "Ilse Reinders and Dorothee Volkert and {de Groot}, {Lisette C P G M} and Beck, {Anne Marie} and Ilana Feldblum and Inken Jobse and Floor Neelemaat and {de van der Schueren}, {Marian A.E.} and Shahar, {Danit R.} and Smeets, {Ellen T.H.C.} and Michael Tieland and Twisk, {Jos W R} and Wijnhoven, {Hanneke A.H.} and Marjolein Visser",
year = "2019",
month = aug,
doi = "10.1016/j.clnu.2018.07.023",
language = "English",
volume = "38",
pages = "1797--1806",
journal = "Clinical Nutrition",
issn = "0733-2327",
publisher = "C.V.Mosby Co.",
number = "4",

}

RIS

TY - JOUR

T1 - Effectiveness of nutritional interventions in older adults at risk of malnutrition across different health care settings: Pooled analyses of individual participant data from nine randomized controlled trials

AU - Reinders, Ilse

AU - Volkert, Dorothee

AU - de Groot, Lisette C P G M

AU - Beck, Anne Marie

AU - Feldblum, Ilana

AU - Jobse, Inken

AU - Neelemaat, Floor

AU - de van der Schueren, Marian A.E.

AU - Shahar, Danit R.

AU - Smeets, Ellen T.H.C.

AU - Tieland, Michael

AU - Twisk, Jos W R

AU - Wijnhoven, Hanneke A.H.

AU - Visser, Marjolein

PY - 2019/8

Y1 - 2019/8

N2 - Background & aims Protein-energy malnutrition is a health concern among older adults. Improving nutritional status by increasing energy and protein intake likely benefits health. We therefore aimed to investigate effects of nutritional interventions in older adults (at risk of malnutrition) on change in energy intake and body weight, and explore if the intervention effect was modified by study or participants’ characteristics, analysing pooled individual participant data. Methods We searched for RCTs investigating the effect of dietary counseling, oral nutritional supplements (ONS) or both on energy intake and weight. Principle investigators of eligible studies provided individual participant data. We investigated the effect of nutritional intervention on meaningful increase in energy intake (>250 kcal/day) and meaningful weight gain (>1.0 kg). Logistic generalized estimating equations were performed and ORs with 95% CIs presented. Results We included data of nine studies with a total of 990 participants, aged 79.2 ± 8.2 years, 64.5% women and mean baseline BMI 23.9 ± 4.7 kg/m2. An non-significant intervention effect was observed for increase in energy intake (OR:1.59; 95% CI 0.95, 2.66) and a significant intervention effect for weight gain (OR:1.58; 95% CI 1.16, 2.17). Stratifying by type of intervention, an intervention effect on increase in energy intake was only observed for dietary counseling in combination with ONS (OR:2.28; 95% CI 1.90, 2.73). The intervention effect on increase in energy intake was greater for women, older participants, and those with lower BMI. Regarding weight gain, an intervention effect was observed for dietary counseling (OR:1.40; 95% CI 1.14, 1.73) and dietary counseling in combination with ONS (OR:2.48; 95% CI 1.92, 3.31). The intervention effect on weight gain was not influenced by participants’ characteristics. Conclusions Based on pooled data of older adults (at risk of malnutrition), nutritional interventions have a positive effect on energy intake and body weight. Dietary counseling combined with ONS is the most effective intervention.

AB - Background & aims Protein-energy malnutrition is a health concern among older adults. Improving nutritional status by increasing energy and protein intake likely benefits health. We therefore aimed to investigate effects of nutritional interventions in older adults (at risk of malnutrition) on change in energy intake and body weight, and explore if the intervention effect was modified by study or participants’ characteristics, analysing pooled individual participant data. Methods We searched for RCTs investigating the effect of dietary counseling, oral nutritional supplements (ONS) or both on energy intake and weight. Principle investigators of eligible studies provided individual participant data. We investigated the effect of nutritional intervention on meaningful increase in energy intake (>250 kcal/day) and meaningful weight gain (>1.0 kg). Logistic generalized estimating equations were performed and ORs with 95% CIs presented. Results We included data of nine studies with a total of 990 participants, aged 79.2 ± 8.2 years, 64.5% women and mean baseline BMI 23.9 ± 4.7 kg/m2. An non-significant intervention effect was observed for increase in energy intake (OR:1.59; 95% CI 0.95, 2.66) and a significant intervention effect for weight gain (OR:1.58; 95% CI 1.16, 2.17). Stratifying by type of intervention, an intervention effect on increase in energy intake was only observed for dietary counseling in combination with ONS (OR:2.28; 95% CI 1.90, 2.73). The intervention effect on increase in energy intake was greater for women, older participants, and those with lower BMI. Regarding weight gain, an intervention effect was observed for dietary counseling (OR:1.40; 95% CI 1.14, 1.73) and dietary counseling in combination with ONS (OR:2.48; 95% CI 1.92, 3.31). The intervention effect on weight gain was not influenced by participants’ characteristics. Conclusions Based on pooled data of older adults (at risk of malnutrition), nutritional interventions have a positive effect on energy intake and body weight. Dietary counseling combined with ONS is the most effective intervention.

KW - Health Sciences

KW - Dietary counseling

KW - Oral nutritional supplements

KW - Protein-energy malnutrition

KW - Undernutrition

KW - Weight gain

KW - Dietary counseling

KW - Oral nutritional supplements

KW - Protein-energy malnutrition

KW - Undernutrition

KW - Weight gain

UR - http://www.scopus.com/inward/record.url?scp=85051411096&partnerID=8YFLogxK

U2 - 10.1016/j.clnu.2018.07.023

DO - 10.1016/j.clnu.2018.07.023

M3 - Journal article

C2 - 30115460

VL - 38

SP - 1797

EP - 1806

JO - Clinical Nutrition

JF - Clinical Nutrition

SN - 0733-2327

IS - 4

M1 - 4

ER -

ID: 56117131