Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Effect of Weight Loss on the Cardiovascular Risk Profile of Obese Patients with Psoriasis

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Wearing Occlusive Gloves Increases the Density of Staphylococcus aureus in Patients with Hand Eczema

    Research output: Contribution to journalJournal articleResearch

  2. Characterization of the Oral and Gut Microbiota in Patients with Psoriatic Diseases: A Systematic Review

    Research output: Contribution to journalReviewResearchpeer-review

  3. Epidemiology of Hyperhidrosis in Danish Blood Donors

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Vaccination Granuloma Itch Treated with Capsaicin 8% Patches

    Research output: Contribution to journalComment/debateResearchpeer-review

View graph of relations

Psoriasis is associated with obesity and other cardiovascular risk factors including endothelial dysfunction. We aimed to investigate the effects of weight loss on the cardiovascular risk profile of obese patients with psoriasis. A randomised controlled study was conducted in which we measured the microvascular endothelial function with peripheral arterial tonometry (PAT), selected plasma markers of endothelial function, and traditional cardiovascular risk factors in 60 obese patients with psoriasis. The participants were randomised to either low-energy diet (n = 30) providing 800-1,000 kcal/day for 8 weeks followed by 8 weeks of reduced food intake reaching 1,200 kcal/day or normal healthy foods (n = 30) for 16 weeks. The intervention group lost significantly more weight than controls, which resulted in significant reductions of diastolic blood pressure, resting heart rate, total cholesterol, VLDL cholesterol, triglyceride, plasma glucose, glycated haemoglobin, and tissue plasminogen activator inhibitor. Microvascular endothelial function assessed by PAT remained unchanged. We conclude that certain components of the cardiovascular risk profile of obese patients with psoriasis can be significantly improved by weight reduction.

Original languageEnglish
JournalActa Dermatovenereologica
Volume94
Issue number6
Pages (from-to)691-4
Number of pages4
ISSN0001-5555
DOIs
Publication statusPublished - 20 Feb 2014

ID: 44447945