Effect of the SK/IK channel modulator 4,5-dichloro-1,3-diethyl-1,3-dihydro-benzoimidazol-2-one (NS4591) on contractile force in rat, pig and human detrusor smooth muscle

Jens Steen Nielsen; Frederik Rode; Mette Rahbek; Karl-Erik Andersson; Lars Christian Rønn; Kirsten Bouchelouche; Jorgen Nordling; Pierre Bouchelouche

doi:10.1111/j.1464-410X.2010.10019.x

Effect of the SK/IK channel modulator 4,5-dichloro-1,3-diethyl-1,3-dihydro-benzoimidazol-2-one (NS4591) on contractile force in rat, pig and human detrusor smooth muscle

Jens Steen Nielsen, Frederik Rode, Mette Rahbek, Karl-Erik Andersson, Lars Christian Rønn, Kirsten Bouchelouche, Jorgen Nordling, Pierre Bouchelouche

13 Citations (Scopus)

Abstract

• To investigate the importance of small (SK)- and intermediate (IK)-conductance Ca2(+) -activated K(+) channels on bladder function, by studying the effects of 4,5-dichloro-1,3-diethyl-1,3-dihydro-benzoimidazol-2-one (NS4591), a new modulator of SK/IK channels, on contractions induced by electrical field stimulation (EFS) and carbachol in rat, pig and human detrusor.

Original language	English
Journal	B J U International (Print)
Volume	108
Issue number	5
Pages (from-to)	771-7
Number of pages	7
ISSN	1464-4096
DOIs	https://doi.org/10.1111/j.1464-410X.2010.10019.x
Publication status	Published - 2011

Keywords

Aged
Animals
Benzimidazoles
Cystectomy
Electric Stimulation
Female
Humans
Male
Middle Aged
Muscle Contraction
Muscle, Smooth
Potassium Channel Blockers
Rats
Rats, Sprague-Dawley
Small-Conductance Calcium-Activated Potassium Channels
Swine
Urinary Bladder
Urinary Bladder Neoplasms

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Nielsen, J. S., Rode, F., Rahbek, M., Andersson, K-E., Rønn, L. C., Bouchelouche, K., Nordling, J., & Bouchelouche, P. (2011). Effect of the SK/IK channel modulator 4,5-dichloro-1,3-diethyl-1,3-dihydro-benzoimidazol-2-one (NS4591) on contractile force in rat, pig and human detrusor smooth muscle. B J U International (Print), 108(5), 771-7. https://doi.org/10.1111/j.1464-410X.2010.10019.x

Effect of the SK/IK channel modulator 4,5-dichloro-1,3-diethyl-1,3-dihydro-benzoimidazol-2-one (NS4591) on contractile force in rat, pig and human detrusor smooth muscle. / Nielsen, Jens Steen; Rode, Frederik; Rahbek, Mette et al.

In: B J U International (Print), Vol. 108, No. 5, 2011, p. 771-7.

Research output: Contribution to journal › Journal article › Research › peer-review

Nielsen, JS, Rode, F, Rahbek, M, Andersson, K-E, Rønn, LC, Bouchelouche, K, Nordling, J & Bouchelouche, P 2011, 'Effect of the SK/IK channel modulator 4,5-dichloro-1,3-diethyl-1,3-dihydro-benzoimidazol-2-one (NS4591) on contractile force in rat, pig and human detrusor smooth muscle', B J U International (Print), vol. 108, no. 5, pp. 771-7. https://doi.org/10.1111/j.1464-410X.2010.10019.x

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title = "Effect of the SK/IK channel modulator 4,5-dichloro-1,3-diethyl-1,3-dihydro-benzoimidazol-2-one (NS4591) on contractile force in rat, pig and human detrusor smooth muscle",

abstract = "• To investigate the importance of small (SK)- and intermediate (IK)-conductance Ca2(+) -activated K(+) channels on bladder function, by studying the effects of 4,5-dichloro-1,3-diethyl-1,3-dihydro-benzoimidazol-2-one (NS4591), a new modulator of SK/IK channels, on contractions induced by electrical field stimulation (EFS) and carbachol in rat, pig and human detrusor.",

keywords = "Aged, Animals, Benzimidazoles, Cystectomy, Electric Stimulation, Female, Humans, Male, Middle Aged, Muscle Contraction, Muscle, Smooth, Potassium Channel Blockers, Rats, Rats, Sprague-Dawley, Small-Conductance Calcium-Activated Potassium Channels, Swine, Urinary Bladder, Urinary Bladder Neoplasms",

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doi = "10.1111/j.1464-410X.2010.10019.x",

language = "English",

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T1 - Effect of the SK/IK channel modulator 4,5-dichloro-1,3-diethyl-1,3-dihydro-benzoimidazol-2-one (NS4591) on contractile force in rat, pig and human detrusor smooth muscle

AU - Nielsen, Jens Steen

AU - Rode, Frederik

AU - Rahbek, Mette

AU - Andersson, Karl-Erik

AU - Rønn, Lars Christian

AU - Bouchelouche, Kirsten

AU - Nordling, Jorgen

AU - Bouchelouche, Pierre

PY - 2011

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N2 - • To investigate the importance of small (SK)- and intermediate (IK)-conductance Ca2(+) -activated K(+) channels on bladder function, by studying the effects of 4,5-dichloro-1,3-diethyl-1,3-dihydro-benzoimidazol-2-one (NS4591), a new modulator of SK/IK channels, on contractions induced by electrical field stimulation (EFS) and carbachol in rat, pig and human detrusor.

AB - • To investigate the importance of small (SK)- and intermediate (IK)-conductance Ca2(+) -activated K(+) channels on bladder function, by studying the effects of 4,5-dichloro-1,3-diethyl-1,3-dihydro-benzoimidazol-2-one (NS4591), a new modulator of SK/IK channels, on contractions induced by electrical field stimulation (EFS) and carbachol in rat, pig and human detrusor.

KW - Aged

KW - Animals

KW - Benzimidazoles

KW - Cystectomy

KW - Electric Stimulation

KW - Female

KW - Humans

KW - Male

KW - Middle Aged

KW - Muscle Contraction

KW - Muscle, Smooth

KW - Potassium Channel Blockers

KW - Rats

KW - Rats, Sprague-Dawley

KW - Small-Conductance Calcium-Activated Potassium Channels

KW - Swine

KW - Urinary Bladder

KW - Urinary Bladder Neoplasms

U2 - 10.1111/j.1464-410X.2010.10019.x

DO - 10.1111/j.1464-410X.2010.10019.x

M3 - Journal article

C2 - 21223472

VL - 108

SP - 771

EP - 777

JO - B J U International (Print)

JF - B J U International (Print)

SN - 1464-4096

IS - 5

ER -

Effect of the SK/IK channel modulator 4,5-dichloro-1,3-diethyl-1,3-dihydro-benzoimidazol-2-one (NS4591) on contractile force in rat, pig and human detrusor smooth muscle

Abstract

Keywords

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