Effect of the direct renin inhibitor aliskiren on left ventricular remodelling following myocardial infarction with systolic dysfunction

Scott D Solomon; Sung Hee Shin; Amil Shah; Hicham Skali; Akshay Desai; Lars Kober; Aldo P Maggioni; Jean L Rouleau; Roxzana Y Kelly; Allen Hester; John J V McMurray; Marc A Pfeffer; Aliskiren Study in Post-MI Patients to Reduce Remodeling (ASPIRE) Investigators

doi:10.1093/eurheartj/ehq522

Effect of the direct renin inhibitor aliskiren on left ventricular remodelling following myocardial infarction with systolic dysfunction

Scott D Solomon, Sung Hee Shin, Amil Shah, Hicham Skali, Akshay Desai, Lars Kober, Aldo P Maggioni, Jean L Rouleau, Roxzana Y Kelly, Allen Hester, John J V McMurray, Marc A Pfeffer, Aliskiren Study in Post-MI Patients to Reduce Remodeling (ASPIRE) Investigators

134 Citations (Scopus)

Abstract

Direct renin inhibitors provide an alternative approach to inhibiting the renin-angiotensin-aldosterone system (RAAS) at the most proximal, specific, and rate-limiting step. We tested the hypothesis that direct renin inhibition would attenuate left ventricular remodelling in patients following acute myocardial infarction receiving stable, individually optimized therapy, including another inhibitor of the RAAS.

Original language	English
Journal	European Heart Journal (English Edition)
Volume	32
Issue number	10
Pages (from-to)	1227-34
Number of pages	8
ISSN	0195-668X
DOIs	https://doi.org/10.1093/eurheartj/ehq522
Publication status	Published - 2011

Keywords

Aged
Amides
Blood Pressure
Cardiotonic Agents
Death, Sudden, Cardiac
Female
Fumarates
Hospitalization
Humans
Male
Middle Aged
Myocardial Infarction
Recurrence
Renin
Systole
Treatment Outcome
Ventricular Dysfunction, Left
Ventricular Remodeling

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Solomon, S. D., Shin, S. H., Shah, A., Skali, H., Desai, A., Kober, L., Maggioni, A. P., Rouleau, J. L., Kelly, R. Y., Hester, A., McMurray, J. J. V., Pfeffer, M. A., & Aliskiren Study in Post-MI Patients to Reduce Remodeling (ASPIRE) Investigators (2011). Effect of the direct renin inhibitor aliskiren on left ventricular remodelling following myocardial infarction with systolic dysfunction. European Heart Journal (English Edition), 32(10), 1227-34. https://doi.org/10.1093/eurheartj/ehq522

Solomon, SD, Shin, SH, Shah, A, Skali, H, Desai, A, Kober, L, Maggioni, AP, Rouleau, JL, Kelly, RY, Hester, A, McMurray, JJV, Pfeffer, MA & Aliskiren Study in Post-MI Patients to Reduce Remodeling (ASPIRE) Investigators 2011, 'Effect of the direct renin inhibitor aliskiren on left ventricular remodelling following myocardial infarction with systolic dysfunction', European Heart Journal (English Edition), vol. 32, no. 10, pp. 1227-34. https://doi.org/10.1093/eurheartj/ehq522

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abstract = "Direct renin inhibitors provide an alternative approach to inhibiting the renin-angiotensin-aldosterone system (RAAS) at the most proximal, specific, and rate-limiting step. We tested the hypothesis that direct renin inhibition would attenuate left ventricular remodelling in patients following acute myocardial infarction receiving stable, individually optimized therapy, including another inhibitor of the RAAS.",

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AU - Kober, Lars

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KW - Amides

KW - Blood Pressure

KW - Cardiotonic Agents

KW - Death, Sudden, Cardiac

KW - Female

KW - Fumarates

KW - Hospitalization

KW - Humans

KW - Male

KW - Middle Aged

KW - Myocardial Infarction

KW - Recurrence

KW - Renin

KW - Systole

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JO - European Heart Journal (English Edition)

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Effect of the direct renin inhibitor aliskiren on left ventricular remodelling following myocardial infarction with systolic dysfunction

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