Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Effect of the 13-valent pneumococcal conjugate vaccine on nasopharyngeal carriage by respiratory pathogens among Greenlandic children

Research output: Contribution to journalJournal articleResearchpeer-review

  1. No association between early maternal HbA1c and offspring birthweight among women without pre-existing diabetes in Greenland

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Diabetes in Greenland - how to deliver diabetes care in a country with a geographically dispersed population

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Gestational diabetes and macrosomia among Greenlanders. Time to change diagnostic strategy?

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Gonorrhoea in Greenland: geographic differences in diagnostic activity and incidence of gonorrhoea in 2015

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Characteristics of Danish children registered with and pharmacologically treated for hypertension

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Poor Head Growth Is Associated with Later Mental Delay among Vietnamese Preterm Infants: A Follow-up Study

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Increase in cognitive function is seen in many single-operated pediatric patients after epilepsy surgery

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Self-Collected versus Healthcare Worker-Collected Swabs in the Diagnosis of Severe Acute Respiratory Syndrome Coronavirus 2

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

BACKGROUND: In 2010, Greenland introduced the 13-valent pneumococcal conjugate vaccine (Prevnar 13®- PCV-13) in the childhood immunisation program. The authors aimed to evaluate the impact of PCV-13 on nasopharyngeal carriage of bacteria frequently associated with respiratory infections in children.

METHOD: In 2013 a cross-sectional population-based study of nasopharyngeal carriage was conducted among Greenlandic children aged 0-6 years and results were compared with an equivalent study from 2011. Nasopharyngeal swab samples were tested for Streptococcus pneumoniae, non-typeable Haemophilus influenzae, Moraxella catarrhalis and Staphylococcus aureus. Pneumococcal serotyping was performed by Quellung reaction and serotype-specific antisera. Statistical analysis included logistic regression models, adjusting for known risk factors.

RESULT: A total of 377 nasopharyngeal samples were collected. Overall carriage rate of S. pneumoniae remained unchanged from 2011 to 2013 (51% and 56%, p=0.13), but significant serotype shifts were observed among both vaccinated and unvaccinated children with marked reductions in carriage of vaccine-type pneumococci, counterbalanced by increasing carriage of non-vaccine types. Carriage rate of S. aureus decreased significantly among vaccinated children whereas that of M. catarrhalis increased.

CONCLUSION: PCV-13 introduction in Greenland is associated with significant changes in nasopharyngeal bacterial carriage. Continued surveillance is warranted to clarify whether these changes are persistent, and affect the pattern of respiratory and invasive diseases in Greenland.

Original languageEnglish
JournalInternational Journal of Circumpolar Health
Volume76
Issue number1
Pages (from-to)e1309504
ISSN1239-9736
DOIs
Publication statusPublished - 2017

    Research areas

  • Journal Article

ID: 52593130