Effect of supine exercise on platelet aggregation and fibrinolytic activity

B Dag, Gitte Gleerup Fornitz, A M Bak, I Hindberg, J Mehlsen, K Winther

    16 Citations (Scopus)

    Abstract

    In 12 healthy young men, strenuous cycling exercise in the supine position, caused platelet aggregability to decrease and the ADP threshold to rise from 7.0 microM resting, to 9.5 exercising (P <0.01). At the same time, fibrinolytic activity increased markedly: euglobulin clot lysis time shortened from 178 to 68 min, PAI-1 fell from 8.91 to 5.16 IU ml-1, and t-PA rose from 0.56 to 3.95 IU ml-1, all three values were significant to P <0.01. When the erect posture was assumed after lying at ease for 1 h after exercise, it did not increase platelet activity as expected, but caused a modest increase of fibrinolytic activity. These results suggest that supine exercise will not affect the haemostatic system adversely.
    Original languageEnglish
    JournalClinical Physiology and Functional Imaging
    Volume14
    Issue number2
    Pages (from-to)181-6
    Number of pages6
    ISSN1475-0961
    Publication statusPublished - 1 Mar 1994

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