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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Effect of simethicone on lactulose-induced H2 production and gastrointestinal symptoms

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  1. Serum neutrophil gelatinase-associated lipocalin - a sensitive novel marker of renal impairment in liver cirrhosis?

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  2. Genetic and environmental factors in monozygotic twins with Crohn's disease and their first-degree relatives: a case report

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  3. NOD2/CARD15 Gene Polymorphisms in Crohn's Disease: A Genotype-Phenotype Analysis in Danish and Portuguese Patients and Controls

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  4. Sweet's syndrome--an extraintestinal manifestation in inflammatory bowel disease

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  1. The association of celiac disease and allergic disease in a general adult population

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  2. Medicinsk Kompendium: Tarmsygdomme

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  3. A low-gluten diet induces changes in the intestinal microbiome of healthy Danish adults

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  4. The distribution of HLA DQ2 and DQ8 haplotypes and their association with health indicators in a general Danish population

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The results of studies of the effect of simethicone on abdominal gas-related symptoms have been contradictory. In a randomized, double-blind cross-over study, 10 healthy volunteers were given 30 g lactulose and 600 mg simethicone or placebo. End-expiratory breath samples were collected and analyzed for H2 and gastrointestinal symptoms registered. There were no differences in biochemical parameters or symptom score between simethicone and placebo. In contrast to previous studies, we used a sufficiently large dose of lactulose to produce gastrointestinal symptoms, a higher dose of simethicone and placebo tablets containing the same additives as the simethicone tablets. There was no demonstrable effect of simethicone on symptoms or intestinal gas production caused by carbohydrate malabsorption.
Original languageEnglish
JournalDigestion
Volume49
Issue number4
Pages (from-to)227-30
Number of pages4
ISSN0012-2823
Publication statusPublished - 1991

    Research areas

  • Adult, Breath Tests, Double-Blind Method, Female, Flatulence, Gastrointestinal Diseases, Humans, Hydrogen, Lactulose, Male, Simethicone

ID: 39696978