Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Effect of probiotic Lactobacillus strains on acute diarrhea in a cohort of nonhospitalized children attending day-care centers

Research output: Contribution to journalJournal articleResearchpeer-review

  1. LISTERIA MENINGITIS IN DANISH CHILDREN 2000-2017: A Rare Event Even in a Country With High Rates of Invasive Listeriosis

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Pediatric Candidemia Epidemiology and Morbidities: A Nationwide Cohort

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Streptococcal Infections and Exacerbations in PANDAS: A Systematic Review and Meta-analysis

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Corrigendum to: Diagnostic Yield of Next-Generation Sequencing in Very Early-Onset Inflammatory Bowel Diseases: A Multicenter Study

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Extraintestinal Manifestations are Associated with Disease Severity in Pediatric Onset Inflammatory Bowel Disease

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Utility of bio-electrical impedance vector analysis for monitoring treatment of severe acute malnutrition in children

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Letter: suicide risk among adult inflammatory bowel disease patients. Authors' reply

    Research output: Contribution to journalLetterResearchpeer-review

View graph of relations

BACKGROUND: Certain strains of lactobacilli have been shown to promote recovery from rotavirus enteritis in hospitalized children. Few studies have examined the effect of probiotics in nonhospitalized children with mild diarrhea.

METHODS: We studied in a randomized placebo-controlled trial the effect of lyophilized Lactobacillus rhamnosus 19070-2 and Lactobacillus reuteri DSM 12246, 10(10) colony-forming units of each strain twice daily for 5 days, on acute diarrhea in children in a cohort of children recruited from local day-care centers. The duration of diarrhea and assessment of stool consistency were recorded by the parents.

RESULTS: In patients treated with the selected Lactobacillus strains, the mean duration of diarrhea after intervention was reduced (76 h in patients treated with probiotics vs. 116 h in the placebo group; P = 0.05). In patients with diarrhea for <60 h before start of treatment (early intervention), a more pronounced effect of probiotics was found. The time to recovery after early treatment was 79 h vs. 139 h in the placebo group (P = 0.02); 1 of 17 patients treated early vs. 6 of 13 in the control group still had loose stools 120 h after start of treatment (P = 0.03).

CONCLUSIONS: In children from day-care centers with mild gastroenteritis, the combination of L. rhamnosus 19070-2 and L. reuteri DSM 12246 was effective in reducing the duration of diarrhea.

Original languageEnglish
JournalThe Pediatric infectious disease journal
Volume21
Issue number5
Pages (from-to)417-9
Number of pages3
ISSN0891-3668
Publication statusPublished - May 2002

    Research areas

  • Acute Disease, Child Day Care Centers, Child, Preschool, Diarrhea, Female, Gastroenteritis, Humans, Infant, Lactobacillus, Male, Outpatients, Probiotics, Time Factors, Treatment Outcome, Clinical Trial, Journal Article, Randomized Controlled Trial

ID: 53671103