Effect of piboserod, a 5-HT4 serotonin receptor antagonist, on left ventricular function in patients with symptomatic heart failure

John K Kjekshus; Christian Torp-Pedersen; Lars Gullestad; Lars Køber; Thor Edvardsen; Inge Olsen; Ivar Sjaastad; Eirik Qvigstad; Tor Skomedal; Jan-Bjørn Osnes; Finn Olav Levy

doi:10.1093/eurjhf/hfp087

Effect of piboserod, a 5-HT4 serotonin receptor antagonist, on left ventricular function in patients with symptomatic heart failure

John K Kjekshus, Christian Torp-Pedersen, Lars Gullestad, Lars Køber, Thor Edvardsen, Inge Olsen, Ivar Sjaastad, Eirik Qvigstad, Tor Skomedal, Jan-Bjørn Osnes, Finn Olav Levy

25 Citations (Scopus)

Abstract

Myocardial 5-HT(4) serotonin (5-HT) receptors are increased and activated in heart failure (HF). Blockade of 5-HT(4) receptors reduced left ventricular (LV) remodelling in HF rats. We evaluated the effect of piboserod, a potent, selective, 5-HT(4) serotonin receptor antagonist, on LV function in patients with HF.

Original language	English
Journal	European journal of heart failure : journal of the Working Group on Heart Failure of the European Society of Cardiology
Volume	11
Issue number	8
Pages (from-to)	771-8
Number of pages	8
DOIs	https://doi.org/10.1093/eurjhf/hfp087
Publication status	Published - 1 Aug 2009

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Kjekshus, J. K., Torp-Pedersen, C., Gullestad, L., Køber, L., Edvardsen, T., Olsen, I., Sjaastad, I., Qvigstad, E., Skomedal, T., Osnes, J.-B., & Levy, F. O. (2009). Effect of piboserod, a 5-HT4 serotonin receptor antagonist, on left ventricular function in patients with symptomatic heart failure. European journal of heart failure : journal of the Working Group on Heart Failure of the European Society of Cardiology, 11(8), 771-8. https://doi.org/10.1093/eurjhf/hfp087

Effect of piboserod, a 5-HT4 serotonin receptor antagonist, on left ventricular function in patients with symptomatic heart failure. / Kjekshus, John K; Torp-Pedersen, Christian; Gullestad, Lars et al.
In: European journal of heart failure : journal of the Working Group on Heart Failure of the European Society of Cardiology, Vol. 11, No. 8, 01.08.2009, p. 771-8.

Research output: Contribution to journal › Journal article › Research › peer-review

Kjekshus, JK, Torp-Pedersen, C, Gullestad, L, Køber, L, Edvardsen, T, Olsen, I, Sjaastad, I, Qvigstad, E, Skomedal, T, Osnes, J-B & Levy, FO 2009, 'Effect of piboserod, a 5-HT4 serotonin receptor antagonist, on left ventricular function in patients with symptomatic heart failure', European journal of heart failure : journal of the Working Group on Heart Failure of the European Society of Cardiology, vol. 11, no. 8, pp. 771-8. https://doi.org/10.1093/eurjhf/hfp087

Kjekshus JK, Torp-Pedersen C, Gullestad L, Køber L, Edvardsen T, Olsen I et al. Effect of piboserod, a 5-HT4 serotonin receptor antagonist, on left ventricular function in patients with symptomatic heart failure. European journal of heart failure : journal of the Working Group on Heart Failure of the European Society of Cardiology. 2009 Aug 1;11(8):771-8. doi: 10.1093/eurjhf/hfp087

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Effect of piboserod, a 5-HT4 serotonin receptor antagonist, on left ventricular function in patients with symptomatic heart failure

Abstract

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