Effect of pamidronate 30 mg versus 90 mg on physical function in patients with newly diagnosed multiple myeloma (Nordic Myeloma Study Group): a double-blind, randomised controlled trial

Peter Gimsing; Kristina Carlson; Ingemar Turesson; Peter Fayers; Anders Waage; Annette Vangsted; Anne Mylin; Christian Gluud; Gunnar Juliusson; Henrik Gregersen; Henrik Hjorth-Hansen; Ingerid Nesthus; Inger Marie Dahl Bahn; Jan Westin; Johan Lanng Nielsen; Lene Meldgaard Knudsen; Lucia Ahlberg; Martin Hjorth; Niels Abildgaard; Niels Frost Andersen; Olle Linder; Finn Wisløff

doi:10.1016/S1470-2045(10)70198-4

Effect of pamidronate 30 mg versus 90 mg on physical function in patients with newly diagnosed multiple myeloma (Nordic Myeloma Study Group): a double-blind, randomised controlled trial

Peter Gimsing, Kristina Carlson, Ingemar Turesson, Peter Fayers, Anders Waage, Annette Vangsted, Anne Mylin, Christian Gluud, Gunnar Juliusson, Henrik Gregersen, Henrik Hjorth-Hansen, Ingerid Nesthus, Inger Marie Dahl Bahn, Jan Westin, Johan Lanng Nielsen, Lene Meldgaard Knudsen, Lucia Ahlberg, Martin Hjorth, Niels Abildgaard, Niels Frost AndersenOlle Linder, Finn Wisløff

Copenhagen Trial Unit

97 Citations (Scopus)

Abstract

Compared with placebo, prophylactic treatment with bisphosphonates reduces risk of skeletal events in patients with multiple myeloma. However, because of toxicity associated with long-term bisphosphonate treatment, establishing the lowest effective dose is important. This study compared the effect of two doses of pamidronate on health-related quality of life and skeletal morbidity in patients with newly diagnosed multiple myeloma.

Original language	English
Journal	Lancet Oncology
Volume	11
Issue number	10
Pages (from-to)	973-82
Number of pages	10
DOIs	https://doi.org/10.1016/S1470-2045(10)70198-4
Publication status	Published - 1 Oct 2010

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Gimsing, P., Carlson, K., Turesson, I., Fayers, P., Waage, A., Vangsted, A., Mylin, A., Gluud, C., Juliusson, G., Gregersen, H., Hjorth-Hansen, H., Nesthus, I., Bahn, I. M. D., Westin, J., Nielsen, J. L., Meldgaard Knudsen, L., Ahlberg, L., Hjorth, M., Abildgaard, N., ... Wisløff, F. (2010). Effect of pamidronate 30 mg versus 90 mg on physical function in patients with newly diagnosed multiple myeloma (Nordic Myeloma Study Group): a double-blind, randomised controlled trial. Lancet Oncology, 11(10), 973-82. https://doi.org/10.1016/S1470-2045(10)70198-4

Effect of pamidronate 30 mg versus 90 mg on physical function in patients with newly diagnosed multiple myeloma (Nordic Myeloma Study Group): a double-blind, randomised controlled trial. / Gimsing, Peter; Carlson, Kristina; Turesson, Ingemar et al.

In: Lancet Oncology, Vol. 11, No. 10, 01.10.2010, p. 973-82.

Research output: Contribution to journal › Journal article › Research › peer-review

Gimsing, P, Carlson, K, Turesson, I, Fayers, P, Waage, A, Vangsted, A , Mylin, A , Gluud, C, Juliusson, G, Gregersen, H, Hjorth-Hansen, H, Nesthus, I, Bahn, IMD, Westin, J, Nielsen, JL, Meldgaard Knudsen, L, Ahlberg, L, Hjorth, M, Abildgaard, N, Andersen, NF, Linder, O & Wisløff, F 2010, 'Effect of pamidronate 30 mg versus 90 mg on physical function in patients with newly diagnosed multiple myeloma (Nordic Myeloma Study Group): a double-blind, randomised controlled trial', Lancet Oncology, vol. 11, no. 10, pp. 973-82. https://doi.org/10.1016/S1470-2045(10)70198-4

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abstract = "Compared with placebo, prophylactic treatment with bisphosphonates reduces risk of skeletal events in patients with multiple myeloma. However, because of toxicity associated with long-term bisphosphonate treatment, establishing the lowest effective dose is important. This study compared the effect of two doses of pamidronate on health-related quality of life and skeletal morbidity in patients with newly diagnosed multiple myeloma.",

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AU - Fayers, Peter

AU - Waage, Anders

AU - Vangsted, Annette

AU - Mylin, Anne

AU - Gluud, Christian

AU - Juliusson, Gunnar

AU - Gregersen, Henrik

AU - Hjorth-Hansen, Henrik

AU - Nesthus, Ingerid

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AU - Westin, Jan

AU - Nielsen, Johan Lanng

AU - Meldgaard Knudsen, Lene

AU - Ahlberg, Lucia

AU - Hjorth, Martin

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AU - Linder, Olle

AU - Wisløff, Finn

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AB - Compared with placebo, prophylactic treatment with bisphosphonates reduces risk of skeletal events in patients with multiple myeloma. However, because of toxicity associated with long-term bisphosphonate treatment, establishing the lowest effective dose is important. This study compared the effect of two doses of pamidronate on health-related quality of life and skeletal morbidity in patients with newly diagnosed multiple myeloma.

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Effect of pamidronate 30 mg versus 90 mg on physical function in patients with newly diagnosed multiple myeloma (Nordic Myeloma Study Group): a double-blind, randomised controlled trial

Abstract

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