Effect of neurokinin A on human temporal muscle blood flow

C Tuxen; K Jensen; M Kjeldsen; L Edvinsson; I Jansen; J Olesen

doi:10.1016/0196-9781(89)90169-1

Effect of neurokinin A on human temporal muscle blood flow

C Tuxen, K Jensen, M Kjeldsen, L Edvinsson, I Jansen, J Olesen

6 Citations (Scopus)

Abstract

The effect of neurokinin A on human temporal muscle blood flow was compared to saline when injected into the muscle in six normal subjects. The 133-Xenon washout technique was used and the test solutions administered in a double-blind, cross-over manner. Neurokinin A (0.02 ml, 10(-5)M) caused a blood flow increase of 193%, while saline caused an increase of 23%. The difference between neurokinin A and saline was significant (p less than 0.05). It is suggested that a possible pathophysiological role of neurokinin A in migraine must involve modulation of vascular response as well as of primary nociception.

Original language	English
Journal	Peptides
Volume	10
Issue number	5
Pages (from-to)	921-4
Number of pages	4
ISSN	0196-9781
DOIs	https://doi.org/10.1016/0196-9781(89)90169-1
Publication status	Published - 1989
Externally published	Yes

Keywords

Adult
Blood Pressure/drug effects
Double-Blind Method
Female
Heart Rate/drug effects
Humans
Male
Mastication/physiology
Masticatory Muscles/drug effects
Neurokinin A/pharmacology
Regional Blood Flow/drug effects
Temporal Muscle/blood supply

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10.1016/0196-9781(89)90169-1

Cite this

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title = "Effect of neurokinin A on human temporal muscle blood flow",

abstract = "The effect of neurokinin A on human temporal muscle blood flow was compared to saline when injected into the muscle in six normal subjects. The 133-Xenon washout technique was used and the test solutions administered in a double-blind, cross-over manner. Neurokinin A (0.02 ml, 10(-5)M) caused a blood flow increase of 193\%, while saline caused an increase of 23\%. The difference between neurokinin A and saline was significant (p less than 0.05). It is suggested that a possible pathophysiological role of neurokinin A in migraine must involve modulation of vascular response as well as of primary nociception.",

keywords = "Adult, Blood Pressure/drug effects, Double-Blind Method, Female, Heart Rate/drug effects, Humans, Male, Mastication/physiology, Masticatory Muscles/drug effects, Neurokinin A/pharmacology, Regional Blood Flow/drug effects, Temporal Muscle/blood supply",

author = "C Tuxen and K Jensen and M Kjeldsen and L Edvinsson and I Jansen and J Olesen",

year = "1989",

doi = "10.1016/0196-9781(89)90169-1",

language = "English",

volume = "10",

pages = "921--4",

journal = "Peptides",

issn = "0196-9781",

publisher = "Elsevier Inc.",

number = "5",

}

TY - JOUR

T1 - Effect of neurokinin A on human temporal muscle blood flow

AU - Tuxen, C

AU - Jensen, K

AU - Kjeldsen, M

AU - Edvinsson, L

AU - Jansen, I

AU - Olesen, J

PY - 1989

Y1 - 1989

N2 - The effect of neurokinin A on human temporal muscle blood flow was compared to saline when injected into the muscle in six normal subjects. The 133-Xenon washout technique was used and the test solutions administered in a double-blind, cross-over manner. Neurokinin A (0.02 ml, 10(-5)M) caused a blood flow increase of 193%, while saline caused an increase of 23%. The difference between neurokinin A and saline was significant (p less than 0.05). It is suggested that a possible pathophysiological role of neurokinin A in migraine must involve modulation of vascular response as well as of primary nociception.

AB - The effect of neurokinin A on human temporal muscle blood flow was compared to saline when injected into the muscle in six normal subjects. The 133-Xenon washout technique was used and the test solutions administered in a double-blind, cross-over manner. Neurokinin A (0.02 ml, 10(-5)M) caused a blood flow increase of 193%, while saline caused an increase of 23%. The difference between neurokinin A and saline was significant (p less than 0.05). It is suggested that a possible pathophysiological role of neurokinin A in migraine must involve modulation of vascular response as well as of primary nociception.

KW - Adult

KW - Blood Pressure/drug effects

KW - Double-Blind Method

KW - Female

KW - Heart Rate/drug effects

KW - Humans

KW - Male

KW - Mastication/physiology

KW - Masticatory Muscles/drug effects

KW - Neurokinin A/pharmacology

KW - Regional Blood Flow/drug effects

KW - Temporal Muscle/blood supply

UR - https://www.scopus.com/pages/publications/0024307043

U2 - 10.1016/0196-9781(89)90169-1

DO - 10.1016/0196-9781(89)90169-1

M3 - Journal article

C2 - 2558365

SN - 0196-9781

VL - 10

SP - 921

EP - 924

JO - Peptides

JF - Peptides

IS - 5

ER -

Effect of neurokinin A on human temporal muscle blood flow

Abstract

Keywords

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