Effect of low-dose heparin on urinary albumin excretion in insulin-dependent diabetes mellitus

B Myrup; P M Hansen; T Jensen; A Kofoed-Enevoldsen; B Feldt-Rasmussen; J Gram; C Kluft; J Jespersen; T Deckert

Effect of low-dose heparin on urinary albumin excretion in insulin-dependent diabetes mellitus

B Myrup, P M Hansen, T Jensen, A Kofoed-Enevoldsen, B Feldt-Rasmussen, J Gram, C Kluft, J Jespersen, T Deckert

95 Citations (Scopus)

Abstract

We investigated the effect of heparin on urinary albumin excretion in patients with insulin-dependent diabetes mellitus. 39 patients with persistent urinary albumin excretion of 30-300 mg/24 h were randomly treated for 3 months with subcutaneous injections twice daily of isotonic saline, 5000 IU unfractionated heparin, or 2000 anti-Xa IU low-molecular-weight heparin. Unfractionated and low-molecular-weight heparin induced a significant reduction in urinary albumin excretion (p = 0.04 and p = 0.004). The mechanism and clinical relevance is unknown but deserve further attention.

Original language	English
Journal	Lancet
Volume	345
Issue number	8947
Pages (from-to)	421-2
Number of pages	2
ISSN	0140-6736
Publication status	Published - 18 Feb 1995

Keywords

Adult
Albuminuria
Diabetes Mellitus, Type 1
Female
Heparin
Heparin, Low-Molecular-Weight
Humans
Male
Middle Aged
Treatment Outcome

Cite this

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title = "Effect of low-dose heparin on urinary albumin excretion in insulin-dependent diabetes mellitus",

abstract = "We investigated the effect of heparin on urinary albumin excretion in patients with insulin-dependent diabetes mellitus. 39 patients with persistent urinary albumin excretion of 30-300 mg/24 h were randomly treated for 3 months with subcutaneous injections twice daily of isotonic saline, 5000 IU unfractionated heparin, or 2000 anti-Xa IU low-molecular-weight heparin. Unfractionated and low-molecular-weight heparin induced a significant reduction in urinary albumin excretion (p = 0.04 and p = 0.004). The mechanism and clinical relevance is unknown but deserve further attention.",

keywords = "Adult, Albuminuria, Diabetes Mellitus, Type 1, Female, Heparin, Heparin, Low-Molecular-Weight, Humans, Male, Middle Aged, Treatment Outcome",

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T1 - Effect of low-dose heparin on urinary albumin excretion in insulin-dependent diabetes mellitus

AU - Myrup, B

AU - Hansen, P M

AU - Jensen, T

AU - Kofoed-Enevoldsen, A

AU - Feldt-Rasmussen, B

AU - Gram, J

AU - Kluft, C

AU - Jespersen, J

AU - Deckert, T

PY - 1995/2/18

Y1 - 1995/2/18

N2 - We investigated the effect of heparin on urinary albumin excretion in patients with insulin-dependent diabetes mellitus. 39 patients with persistent urinary albumin excretion of 30-300 mg/24 h were randomly treated for 3 months with subcutaneous injections twice daily of isotonic saline, 5000 IU unfractionated heparin, or 2000 anti-Xa IU low-molecular-weight heparin. Unfractionated and low-molecular-weight heparin induced a significant reduction in urinary albumin excretion (p = 0.04 and p = 0.004). The mechanism and clinical relevance is unknown but deserve further attention.

AB - We investigated the effect of heparin on urinary albumin excretion in patients with insulin-dependent diabetes mellitus. 39 patients with persistent urinary albumin excretion of 30-300 mg/24 h were randomly treated for 3 months with subcutaneous injections twice daily of isotonic saline, 5000 IU unfractionated heparin, or 2000 anti-Xa IU low-molecular-weight heparin. Unfractionated and low-molecular-weight heparin induced a significant reduction in urinary albumin excretion (p = 0.04 and p = 0.004). The mechanism and clinical relevance is unknown but deserve further attention.

KW - Adult

KW - Albuminuria

KW - Diabetes Mellitus, Type 1

KW - Female

KW - Heparin

KW - Heparin, Low-Molecular-Weight

KW - Humans

KW - Male

KW - Middle Aged

KW - Treatment Outcome

UR - https://www.scopus.com/pages/publications/0028939366

M3 - Journal article

C2 - 7853952

SN - 0140-6736

VL - 345

SP - 421

EP - 422

JO - Lancet

JF - Lancet

IS - 8947

ER -

Effect of low-dose heparin on urinary albumin excretion in insulin-dependent diabetes mellitus

Abstract

Keywords

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