Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Effect of Losartan on the Acute Response of Human Elderly Skeletal Muscle to Exercise

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Neuromuscular Fatigue and Metabolism during High-Intensity Intermittent Exercise

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Aerobic Exercise Performance and Muscle Strength in Statin Users-The LIFESTAT Study

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Time Trial Performance Is Sensitive to Low-Volume Autologous Blood Transfusion

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Dynamic Cerebral Autoregulation Is Maintained during High-Intensity Interval Exercise

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Impact of a Graded Exercise Program on V˙O2peak and Survival in Heart Failure Patients

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Maintenance of muscle strength following a one-year resistance training program in older adults

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. The influence of prolonged strength training upon muscle and fat in healthy and chronically diseased older adults

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Cardiovascular and metabolic health effects of team handball training in overweight women: Impact of prior experience

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. The effect of 4 months exercise training on systemic biomarkers of cartilage and bone turnover in hip osteoarthritis patients

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Early development of tendinopathy in humans: Sequence of pathological changes in structure and tissue turnover signaling

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

PURPOSE: To investigate the effect of blocking the angiotensin II Type I receptor (AT1R) upon the response to acute heavy-resistance exercise in elderly human skeletal muscle. The hypothesis was that AT1R blocking would result in a superior myogenic response accompanied by down-regulation of transforming growth factor-beta and up-regulation of insulin-like growth factor-1 signaling.

METHODS: Twenty-eight healthy elderly men (+64 yr) were randomized into two groups, consuming either AT1R blocker (losartan, 100 mg·d) or placebo for 18 d before exercise. Participants performed one bout of heavy-unilateral-resistance exercise. Six muscle biopsies were obtained from the vastus lateralis muscles of each subject: two before exercise and four after exercise (4.5 h and 1, 4, and 7 d). Blood pressure and blood samples were collected at the same time points. Biopsies were sectioned for immunohistochemistry to determine the number of satellite cells associated with Type I and Type II fibers. Gene expression levels of Notch, connective tissue, and myogenic signaling pathways were determined by real-time reverse transcription polymerase chain reaction.

RESULTS: Changes over time were detected for circulating creatine kinase, the number of satellite cells per Type I fiber, and most of the gene targets, with no specific effect of losartan on these. However, when compared with placebo, losartan intake resulted in a greater suppression of myostatin messenger RNA.

CONCLUSIONS: In general, there does not seem to be any effect of AT1R blocking on satellite cell number or myogenic pathways in elderly men in the days after one bout of heavy-resistance exercise. However, the greater suppression of myostatin may prove to be beneficial over a long-term intervention designed to induce hypertrophy.

Original languageEnglish
JournalMedicine and Science in Sports and Exercise
Volume50
Issue number2
Pages (from-to)225-235
Number of pages11
ISSN0195-9131
DOIs
Publication statusPublished - Feb 2018

    Research areas

  • Aged, Aged, 80 and over, Angiotensin II Type 1 Receptor Blockers/pharmacology, Double-Blind Method, Exercise, Humans, Losartan/pharmacology, Male, Middle Aged, Muscle, Skeletal/drug effects, Myostatin/metabolism, RNA, Messenger/metabolism, Resistance Training, Satellite Cells, Skeletal Muscle

ID: 56333010