Effect of lifelong resveratrol supplementation and exercise training on skeletal muscle oxidative capacity in aging mice; impact of PGC-1α

Stine Ringholm; Jesper Olesen; Jesper Thorhauge Pedersen; Christina Tingbjerg Brandt; Jens Frey Halling; Ylva Hellsten; Clara Prats; Henriette Pilegaard

doi:10.1016/j.exger.2013.08.012

Effect of lifelong resveratrol supplementation and exercise training on skeletal muscle oxidative capacity in aging mice; impact of PGC-1α

Stine Ringholm, Jesper Olesen, Jesper Thorhauge Pedersen, Christina Tingbjerg Brandt, Jens Frey Halling, Ylva Hellsten, Clara Prats, Henriette Pilegaard

58 Citations (Scopus)

Abstract

The present study tested the hypothesis that lifelong resveratrol (RSV) supplementation counteracts an age-associated decrease in skeletal muscle oxidative capacity through peroxisome proliferator-activated receptor-γ coactivator (PGC)-1α and that RSV combined with lifelong exercise training (EX) exerts additive effects through PGC-1α in mice.

Original language	English
Journal	Experimental Gerontology
Volume	48
Issue number	11
Pages (from-to)	1311-8
Number of pages	8
ISSN	0531-5565
DOIs	https://doi.org/10.1016/j.exger.2013.08.012
Publication status	Published - Nov 2013

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10.1016/j.exger.2013.08.012

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abstract = "The present study tested the hypothesis that lifelong resveratrol (RSV) supplementation counteracts an age-associated decrease in skeletal muscle oxidative capacity through peroxisome proliferator-activated receptor-γ coactivator (PGC)-1α and that RSV combined with lifelong exercise training (EX) exerts additive effects through PGC-1α in mice.",

author = "Stine Ringholm and Jesper Olesen and Pedersen, \{Jesper Thorhauge\} and Brandt, \{Christina Tingbjerg\} and Halling, \{Jens Frey\} and Ylva Hellsten and Clara Prats and Henriette Pilegaard",

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T1 - Effect of lifelong resveratrol supplementation and exercise training on skeletal muscle oxidative capacity in aging mice; impact of PGC-1α

AU - Ringholm, Stine

AU - Olesen, Jesper

AU - Pedersen, Jesper Thorhauge

AU - Brandt, Christina Tingbjerg

AU - Halling, Jens Frey

AU - Hellsten, Ylva

AU - Prats, Clara

AU - Pilegaard, Henriette

PY - 2013/11

Y1 - 2013/11

N2 - The present study tested the hypothesis that lifelong resveratrol (RSV) supplementation counteracts an age-associated decrease in skeletal muscle oxidative capacity through peroxisome proliferator-activated receptor-γ coactivator (PGC)-1α and that RSV combined with lifelong exercise training (EX) exerts additive effects through PGC-1α in mice.

AB - The present study tested the hypothesis that lifelong resveratrol (RSV) supplementation counteracts an age-associated decrease in skeletal muscle oxidative capacity through peroxisome proliferator-activated receptor-γ coactivator (PGC)-1α and that RSV combined with lifelong exercise training (EX) exerts additive effects through PGC-1α in mice.

UR - https://www.scopus.com/pages/publications/84884167145

U2 - 10.1016/j.exger.2013.08.012

DO - 10.1016/j.exger.2013.08.012

M3 - Journal article

C2 - 23994519

SN - 0531-5565

VL - 48

SP - 1311

EP - 1318

JO - Experimental Gerontology

JF - Experimental Gerontology

IS - 11

ER -

Effect of lifelong resveratrol supplementation and exercise training on skeletal muscle oxidative capacity in aging mice; impact of PGC-1α

Abstract

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