Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Effect of Intracoronary and Intravenous Melatonin on Myocardial Salvage Index in Patients with ST-Elevation Myocardial Infarction: a Randomized Placebo Controlled Trial

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Amiodarone Treatment in the Early Phase of Acute Myocardial Infarction Protects Against Ventricular Fibrillation in a Porcine Model

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Pharmacological attenuation of myocardial reperfusion injury in a closed-chest porcine model: a systematic review

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Hypertrophy signaling pathways in experimental chronic aortic regurgitation

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Most Cochrane reviews have not been updated formore than 5 years

    Research output: Contribution to journalLetterResearchpeer-review

  2. Surgeon Volume and Risk of Reoperation after Laparoscopic Primary Ventral Hernia Repair: A Nationwide Register-Based Study

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Younger age at onset of colorectal cancer is associated with increased patient's delay

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Surgical techniques for repair of abdominal rectus diastasis: a scoping review

    Research output: Contribution to journalReviewResearchpeer-review

  5. Time from submission to publication varied widely for biomedical journals: a systematic review

    Research output: Contribution to journalReviewResearchpeer-review

View graph of relations

Melatonin has attenuated myocardial ischemia reperfusion injury in experimental studies. We hypothesized that the administration of melatonin during acute myocardial reperfusion improves myocardial salvage index in patients with ST-elevation myocardial infarction. Patients (n = 48) were randomized in a 1:1 ratio to intracoronary and intravenous melatonin (total 50 mg) or placebo. The myocardial salvage index assessed by cardiac magnetic resonance imaging at day 4 (± 1 day) after primary percutaneous coronary intervention was similar in the melatonin group (n = 22) at 55.3% (95% CI 47.0-63.6) and the placebo group (n = 19) at 61.5% (95% CI 57.5-65.5), p = 0.21. The levels of high-sensitive troponin T, creatinine kinase myocardial band, and oxidative biomarkers (advanced oxidation protein products, malondialdehyde, myeloperoxidase) were similar in the groups. The frequency of clinical events at 90 days did not differ between the groups. In conclusion, melatonin did not improve the myocardial salvage index after primary percutaneous coronary intervention in patients with ST elevation myocardial infarction compared with placebo.

Original languageEnglish
JournalJournal of Cardiovascular Translational Research
Volume10
Issue number5-6
Pages (from-to)470-479
Number of pages10
ISSN1937-5387
DOIs
Publication statusPublished - Dec 2017

    Research areas

  • Journal Article

ID: 52407312