Effect of Influenza Vaccination on Risk of Coronavirus Disease 2019: A Prospective Cohort Study of 46 000 Healthcare Workers

Jonas Henrik Kristensen; Rasmus Bo Hasselbalch; Mia Pries-Heje; Pernille Brok Nielsen; Andreas Dehlbæk Knudsen; Kamille Fogh; Jakob Boesgaard Norsk; Aleksander Eiken; Ove Andersen; Thea Kølsen Fischer; Claus Antonio Juul Jensen; Christian Torp-Pedersen; Jørgen Rungby; Sisse Bolm Ditlev; Ida Hageman; Rasmus Møgelvang; Mikkel Gybel-Brask; Ram Benny Dessau; Erik Sørensen; Lene Harritshøj; Fredrik Folke; Maria Elizabeth Engel Møller; Thomas Benfield; Henrik Ullum; Charlotte Sværke Jørgensen; Sisse Rye Ostrowski; Susanne Dam Nielsen; Henning Bundgaard; Kasper Iversen

doi:10.1093/infdis/jiac001

Effect of Influenza Vaccination on Risk of Coronavirus Disease 2019: A Prospective Cohort Study of 46 000 Healthcare Workers

Jonas Henrik Kristensen^*, Rasmus Bo Hasselbalch, Mia Pries-Heje, Pernille Brok Nielsen, Andreas Dehlbæk Knudsen, Kamille Fogh, Jakob Boesgaard Norsk, Aleksander Eiken, Ove Andersen, Thea Kølsen Fischer, Claus Antonio Juul Jensen, Christian Torp-Pedersen, Jørgen Rungby, Sisse Bolm Ditlev, Ida Hageman, Rasmus Møgelvang, Mikkel Gybel-Brask, Ram Benny Dessau, Erik Sørensen, Lene HarritshøjFredrik Folke, Maria Elizabeth Engel Møller, Thomas Benfield, Henrik Ullum, Charlotte Sværke Jørgensen, Sisse Rye Ostrowski, Susanne Dam Nielsen, Henning Bundgaard, Kasper Iversen

^*Corresponding author for this work

Abstract

BACKGROUND: The purpose of this study was to assess whether influenza vaccination has an impact on the risk of coronavirus disease 2019 (COVID-19).

METHODS: A cohort of 46 112 healthcare workers were tested for antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and filled in a survey on COVID-19 symptoms, hospitalization, and influenza vaccination.

RESULTS: The risk ratio of hospitalization due to SARS-CoV-2 for influenza vaccinated compared with unvaccinated participants was 1.00 for the seasonal vaccination in 2019/2020 (confidence interval, .56-1.78, P = 1.00). Likewise, no clinical effect of influenza vaccination on development of antibodies against SARS-CoV-2 was found.

CONCLUSIONS: The present findings indicate that influenza vaccination does not affect the risk of SARS-CoV-2 infection or COVID-19.

Original language	English
Article number	jiac001
Journal	The Journal of infectious diseases
Volume	226
Issue number	1
Pages (from-to)	6-10
Number of pages	5
ISSN	0022-1899
DOIs	https://doi.org/10.1093/infdis/jiac001
Publication status	Published - Jul 2022

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Kristensen, J. H., Hasselbalch, R. B., Pries-Heje, M., Nielsen, P. B., Dehlbæk Knudsen, A., Fogh, K., Boesgaard Norsk, J., Eiken, A., Andersen, O., Fischer, T. K., Juul Jensen, C. A., Torp-Pedersen, C., Rungby, J., Ditlev, S. B., Hageman, I., Møgelvang, R., Gybel-Brask, M., Dessau, R. B., Sørensen, E., ... Iversen, K. (2022). Effect of Influenza Vaccination on Risk of Coronavirus Disease 2019: A Prospective Cohort Study of 46 000 Healthcare Workers. The Journal of infectious diseases, 226(1), 6-10. [jiac001]. https://doi.org/10.1093/infdis/jiac001

Effect of Influenza Vaccination on Risk of Coronavirus Disease 2019: A Prospective Cohort Study of 46 000 Healthcare Workers. / Kristensen, Jonas Henrik; Hasselbalch, Rasmus Bo; Pries-Heje, Mia et al.

In: The Journal of infectious diseases, Vol. 226, No. 1, jiac001, 07.2022, p. 6-10.

Research output: Contribution to journal › Journal article › Research › peer-review

Kristensen, JH, Hasselbalch, RB, Pries-Heje, M, Nielsen, PB, Dehlbæk Knudsen, A, Fogh, K, Boesgaard Norsk, J, Eiken, A , Andersen, O , Fischer, TK , Juul Jensen, CA , Torp-Pedersen, C , Rungby, J , Ditlev, SB , Hageman, I , Møgelvang, R , Gybel-Brask, M, Dessau, RB, Sørensen, E , Harritshøj, L , Folke, F, Engel Møller, ME, Benfield, T, Ullum, H, Jørgensen, CS, Rye Ostrowski, S , Nielsen, SD , Bundgaard, H & Iversen, K 2022, 'Effect of Influenza Vaccination on Risk of Coronavirus Disease 2019: A Prospective Cohort Study of 46 000 Healthcare Workers', The Journal of infectious diseases, vol. 226, no. 1, jiac001, pp. 6-10. https://doi.org/10.1093/infdis/jiac001

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title = "Effect of Influenza Vaccination on Risk of Coronavirus Disease 2019: A Prospective Cohort Study of 46 000 Healthcare Workers",

abstract = "BACKGROUND: The purpose of this study was to assess whether influenza vaccination has an impact on the risk of coronavirus disease 2019 (COVID-19).METHODS: A cohort of 46 112 healthcare workers were tested for antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and filled in a survey on COVID-19 symptoms, hospitalization, and influenza vaccination.RESULTS: The risk ratio of hospitalization due to SARS-CoV-2 for influenza vaccinated compared with unvaccinated participants was 1.00 for the seasonal vaccination in 2019/2020 (confidence interval, .56-1.78, P = 1.00). Likewise, no clinical effect of influenza vaccination on development of antibodies against SARS-CoV-2 was found.CONCLUSIONS: The present findings indicate that influenza vaccination does not affect the risk of SARS-CoV-2 infection or COVID-19.",

author = "Kristensen, {Jonas Henrik} and Hasselbalch, {Rasmus Bo} and Mia Pries-Heje and Nielsen, {Pernille Brok} and {Dehlb{\ae}k Knudsen}, Andreas and Kamille Fogh and {Boesgaard Norsk}, Jakob and Aleksander Eiken and Ove Andersen and Fischer, {Thea K{\o}lsen} and {Juul Jensen}, {Claus Antonio} and Christian Torp-Pedersen and J{\o}rgen Rungby and Ditlev, {Sisse Bolm} and Ida Hageman and Rasmus M{\o}gelvang and Mikkel Gybel-Brask and Dessau, {Ram Benny} and Erik S{\o}rensen and Lene Harritsh{\o}j and Fredrik Folke and {Engel M{\o}ller}, {Maria Elizabeth} and Thomas Benfield and Henrik Ullum and J{\o}rgensen, {Charlotte Sv{\ae}rke} and {Rye Ostrowski}, Sisse and Nielsen, {Susanne Dam} and Henning Bundgaard and Kasper Iversen",

note = "{\textcopyright} The Author(s) 2022. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.",

year = "2022",

month = jul,

doi = "10.1093/infdis/jiac001",

language = "English",

volume = "226",

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issn = "0022-1899",

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T1 - Effect of Influenza Vaccination on Risk of Coronavirus Disease 2019: A Prospective Cohort Study of 46 000 Healthcare Workers

AU - Kristensen, Jonas Henrik

AU - Hasselbalch, Rasmus Bo

AU - Pries-Heje, Mia

AU - Nielsen, Pernille Brok

AU - Dehlbæk Knudsen, Andreas

AU - Fogh, Kamille

AU - Boesgaard Norsk, Jakob

AU - Eiken, Aleksander

AU - Andersen, Ove

AU - Fischer, Thea Kølsen

AU - Juul Jensen, Claus Antonio

AU - Torp-Pedersen, Christian

AU - Rungby, Jørgen

AU - Ditlev, Sisse Bolm

AU - Hageman, Ida

AU - Møgelvang, Rasmus

AU - Gybel-Brask, Mikkel

AU - Dessau, Ram Benny

AU - Sørensen, Erik

AU - Harritshøj, Lene

AU - Folke, Fredrik

AU - Engel Møller, Maria Elizabeth

AU - Benfield, Thomas

AU - Ullum, Henrik

AU - Jørgensen, Charlotte Sværke

AU - Rye Ostrowski, Sisse

AU - Nielsen, Susanne Dam

AU - Bundgaard, Henning

AU - Iversen, Kasper

PY - 2022/7

Y1 - 2022/7

N2 - BACKGROUND: The purpose of this study was to assess whether influenza vaccination has an impact on the risk of coronavirus disease 2019 (COVID-19).METHODS: A cohort of 46 112 healthcare workers were tested for antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and filled in a survey on COVID-19 symptoms, hospitalization, and influenza vaccination.RESULTS: The risk ratio of hospitalization due to SARS-CoV-2 for influenza vaccinated compared with unvaccinated participants was 1.00 for the seasonal vaccination in 2019/2020 (confidence interval, .56-1.78, P = 1.00). Likewise, no clinical effect of influenza vaccination on development of antibodies against SARS-CoV-2 was found.CONCLUSIONS: The present findings indicate that influenza vaccination does not affect the risk of SARS-CoV-2 infection or COVID-19.

AB - BACKGROUND: The purpose of this study was to assess whether influenza vaccination has an impact on the risk of coronavirus disease 2019 (COVID-19).METHODS: A cohort of 46 112 healthcare workers were tested for antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and filled in a survey on COVID-19 symptoms, hospitalization, and influenza vaccination.RESULTS: The risk ratio of hospitalization due to SARS-CoV-2 for influenza vaccinated compared with unvaccinated participants was 1.00 for the seasonal vaccination in 2019/2020 (confidence interval, .56-1.78, P = 1.00). Likewise, no clinical effect of influenza vaccination on development of antibodies against SARS-CoV-2 was found.CONCLUSIONS: The present findings indicate that influenza vaccination does not affect the risk of SARS-CoV-2 infection or COVID-19.

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VL - 226

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JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

SN - 0022-1899

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Effect of Influenza Vaccination on Risk of Coronavirus Disease 2019: A Prospective Cohort Study of 46 000 Healthcare Workers

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