Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Effect of Increased Potassium Intake on Adrenal Cortical and Cardiovascular Responses to Angiotensin II: A Randomized Crossover Study

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Incidence of Infective Endocarditis Among Patients With Tetralogy of Fallot

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Lifetime Risk of Heart Failure and Trends in Incidence Rates Among Individuals With Type 2 Diabetes Between 1995 and 2018

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Long-Term Exposure to Air Pollution, Road Traffic Noise, and Heart Failure Incidence: The Danish Nurse Cohort

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Comprehensive Physiological Modeling Provides Novel Insights Into Heart Failure With Preserved Ejection Fraction Physiology

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Academic performance in adolescents born to mothers with gestational diabetes - a national Danish cohort study

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Five years of treatment with liraglutide improves glucose tolerance in women with prior gestational diabetes, but effects are lost after washout

    Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

  3. Intensive Lifestyle Intervention Increases Plasma Midregional Proatrial Natriuretic Peptide Concentrations in Overweight Children

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

Background Increased potassium intake lowers blood pressure in patients with hypertension, but increased potassium intake also elevates plasma concentrations of the blood pressure-raising hormone aldosterone. Besides its well-described renal effects, aldosterone is also believed to have vascular effects, acting through mineralocorticoid receptors present in endothelial and vascular smooth muscle cells, although mineralocorticoid receptors-independent actions are also thought to be involved. Methods and Results To gain further insight into the effect of increased potassium intake and potassium-stimulated hyperaldosteronism on the human cardiovascular system, we conducted a randomized placebo-controlled double-blind crossover study in 25 healthy normotensive men, where 4 weeks treatment with a potassium supplement (90 mmol/day) was compared with 4 weeks on placebo. At the end of each treatment period, we measured potassium and aldosterone in plasma and performed an angiotensin II (AngII) infusion experiment, during which we assessed the aldosterone response in plasma. Hemodynamics were also monitored during the AngII infusion using ECG, impedance cardiography, finger plethysmography (blood pressure-monitoring), and Doppler ultrasound. The study showed that higher potassium intake increased plasma potassium (mean±SD, 4.3±0.2 versus 4.0±0.2 mmol/L; P=0.0002) and aldosterone (median [interquartile range], 440 [336-521] versus 237 [173-386] pmol/L; P<0.0001), and based on a linear mixed model for repeated measurements, increased potassium intake potentiated AngII-stimulated aldosterone secretion (P=0.0020). In contrast, the hemodynamic responses (blood pressure, total peripheral resistance, cardiac output, and renal artery blood flow) to AngII were similar after potassium and placebo. Conclusions Increased potassium intake potentiates AngII-stimulated aldosterone secretion without affecting systemic cardiovascular hemodynamics in healthy normotensive men. Registration EudraCT Number: 2013-004460-66; URL: https://www.ClinicalTrials.gov; Unique identifier: NCT02380157.

Original languageEnglish
Article numbere018716
JournalJournal of the American Heart Association
Volume10
Issue number9
ISSN2047-9980
DOIs
Publication statusPublished - 4 May 2021

Bibliographical note

Publisher Copyright:
© 2021 The Authors.

Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.

    Research areas

  • Aldosterone, Angiotensin, Angiotensin II, Blood pressure, Hemodynamics, Potassium

ID: 65018177