Effect of high-dose preoperative methylprednisolone on pain and recovery after total knee arthroplasty: a randomized, placebo-controlled trial

Troels Lunn; Billy Bjarne Kristensen; Lasse Andersen; H Husted; Niels Kristian Stahl Otte; L Gaarn-Larsen; Henrik Kehlet

doi:10.1093/bja/aeq333

Effect of high-dose preoperative methylprednisolone on pain and recovery after total knee arthroplasty: a randomized, placebo-controlled trial

Troels Lunn, Billy Bjarne Kristensen, Lasse Andersen, H Husted, Niels Kristian Stahl Otte, L Gaarn-Larsen, Henrik Kehlet

243 Citations (Scopus)

Abstract

Total knee arthroplasty (TKA) is associated with severe pain and inflammation despite an extensive multimodal analgesic approach, but the effect of high-dose glucocorticoid administration has not been studied.

Original language	English
Journal	British Journal of Anaesthesia
Volume	106
Issue number	2
Pages (from-to)	230-8
Number of pages	8
ISSN	0007-0912
DOIs	https://doi.org/10.1093/bja/aeq333
Publication status	Published - 2011

Keywords

Aged
Aged, 80 and over
Analgesics, Opioid
Anesthesia, Spinal
Antiemetics
Arthroplasty, Replacement, Knee
C-Reactive Protein
Double-Blind Method
Drug Administration Schedule
Female
Glucocorticoids
Humans
Male
Methylprednisolone
Middle Aged
Oxycodone
Pain Measurement
Pain, Postoperative
Postoperative Care
Postoperative Nausea and Vomiting
Preanesthetic Medication

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10.1093/bja/aeq333

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title = "Effect of high-dose preoperative methylprednisolone on pain and recovery after total knee arthroplasty: a randomized, placebo-controlled trial",

abstract = "Total knee arthroplasty (TKA) is associated with severe pain and inflammation despite an extensive multimodal analgesic approach, but the effect of high-dose glucocorticoid administration has not been studied.",

keywords = "Aged, Aged, 80 and over, Analgesics, Opioid, Anesthesia, Spinal, Antiemetics, Arthroplasty, Replacement, Knee, C-Reactive Protein, Double-Blind Method, Drug Administration Schedule, Female, Glucocorticoids, Humans, Male, Methylprednisolone, Middle Aged, Oxycodone, Pain Measurement, Pain, Postoperative, Postoperative Care, Postoperative Nausea and Vomiting, Preanesthetic Medication",

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T1 - Effect of high-dose preoperative methylprednisolone on pain and recovery after total knee arthroplasty: a randomized, placebo-controlled trial

AU - Lunn, Troels

AU - Kristensen, Billy Bjarne

AU - Andersen, Lasse

AU - Husted, H

AU - Otte, Niels Kristian Stahl

AU - Gaarn-Larsen, L

AU - Kehlet, Henrik

PY - 2011

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N2 - Total knee arthroplasty (TKA) is associated with severe pain and inflammation despite an extensive multimodal analgesic approach, but the effect of high-dose glucocorticoid administration has not been studied.

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KW - Aged, 80 and over

KW - Analgesics, Opioid

KW - Anesthesia, Spinal

KW - Antiemetics

KW - Arthroplasty, Replacement, Knee

KW - C-Reactive Protein

KW - Double-Blind Method

KW - Drug Administration Schedule

KW - Female

KW - Glucocorticoids

KW - Humans

KW - Male

KW - Methylprednisolone

KW - Middle Aged

KW - Oxycodone

KW - Pain Measurement

KW - Pain, Postoperative

KW - Postoperative Care

KW - Postoperative Nausea and Vomiting

KW - Preanesthetic Medication

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SN - 0007-0912

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JO - British Journal of Anaesthesia

JF - British Journal of Anaesthesia

IS - 2

ER -

Effect of high-dose preoperative methylprednisolone on pain and recovery after total knee arthroplasty: a randomized, placebo-controlled trial

Abstract

Keywords

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