Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Effect of endurance versus resistance training on quadriceps muscle dysfunction in COPD: a pilot study

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Burn injury during long-term oxygen therapy in Denmark and Sweden: the potential role of smoking

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. General practitioners' perceptions of COPD treatment: thematic analysis of qualitative interviews

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Point-of-care procalcitonin test to reduce antibiotic exposure in patients hospitalized with acute exacerbation of COPD

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Muscle-liver substrate fluxes in exercising humans and potential effects on hepatic metabolism

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Development of limb muscle dysfunction in chronic obstructive pulmonary disease: Smoking, inflammation, or simply disuse?

    Research output: Contribution to journalEditorialResearchpeer-review

  3. Epigenome- and Transcriptome-wide Changes in Muscle Stem Cells from Low Birth Weight Men

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

INTRODUCTION: Exercise is an important countermeasure to limb muscle dysfunction in COPD. The two major training modalities in COPD rehabilitation, endurance training (ET) and resistance training (RT), may both be efficient in improving muscle strength, exercise capacity, and health-related quality of life, but the effects on quadriceps muscle characteristics have not been thoroughly described.

METHODS: Thirty COPD patients (forced expiratory volume in 1 second: 56% of predicted, standard deviation [SD] 14) were randomized to 8 weeks of ET or RT. Vastus lateralis muscle biopsies were obtained before and after the training intervention to assess muscle morphology and metabolic and angiogenic factors. Symptom burden, exercise capacity (6-minute walking and cycle ergometer tests), and vascular function were also assessed.

RESULTS: Both training modalities improved symptom burden and exercise capacity with no difference between the two groups. The mean (SD) proportion of glycolytic type IIa muscle fibers was reduced after ET (from 48% [SD 11] to 42% [SD 10], P<0.05), whereas there was no significant change in muscle fiber distribution with RT. There was no effect of either training modality on muscle capillarization, angiogenic factors, or vascular function. After ET the muscle protein content of phosphofructokinase was reduced (P<0.05) and the citrate synthase content tended increase (P=0.08) but no change was observed after RT.

CONCLUSION: Although both ET and RT improve symptoms and exercise capacity, ET induces a more oxidative quadriceps muscle phenotype, counteracting muscle dysfunction in COPD.

Original languageEnglish
JournalInternational journal of chronic obstructive pulmonary disease
Volume11
Pages (from-to)2659-2669
Number of pages11
ISSN1178-2005
DOIs
Publication statusPublished - Dec 2016

ID: 49465659