Effect of diagnostic criteria on prevalence of frontotemporal dementia in the elderly

Thorsteinn B Gislason; Svante Östling; Anne Börjesson-Hanson; Magnus Sjögren; Michela Simoni; Leonardo Pantoni; Ingmar Skoog

doi:10.1016/j.jalz.2014.03.002

Effect of diagnostic criteria on prevalence of frontotemporal dementia in the elderly

Thorsteinn B Gislason
, Svante Östling
, Anne Börjesson-Hanson
, Magnus Sjögren
, Michela Simoni
, Leonardo Pantoni
, Ingmar Skoog

6 Citations (Scopus)

Abstract

BACKGROUND: Frontotemporal dementia (FTD) is believed to be rare in the elderly, and the influence of different criteria on the prevalence of FTD is unclear.

METHODS: Population-based samples of 70- to 95-year-olds (n = 2462) in Gothenburg, Sweden, underwent neuropsychiatric examinations. Behavioral variant FTD (bvFTD) was diagnosed according to the International Behavioural Variant FTD Criteria Consortium (FTDC), the Frontotemporal Lobe Degeneration Consensus criteria, and the Lund-Manchester Research Criteria. A subset (n = 1074) underwent computerized tomography (CT) of the brain.

RESULTS: The prevalence of bvFTD varied between 0.2% and 0.5% at age 70 to 79 years, between 2.5% and 3.6% at age 80 to 89 years, and between 1.7% and 2.2% at age 90 to 95 years. The agreement between different criteria was low to moderate (κ = 0.20-0.42). Among those with bvFTD according to FTDC, 93.3% had frontal and/or temporal lobar atrophy on CT, compared with 12.6% of those without bvFTD (P < .001).

CONCLUSIONS: The prevalence of bvFTD was higher than expected in this population. To a large extent, different criteria captured different individuals.

Original language	English
Journal	Alzheimer's & dementia : the journal of the Alzheimer's Association
Volume	11
Issue number	4
Pages (from-to)	425-33
Number of pages	9
ISSN	1552-5260
DOIs	https://doi.org/10.1016/j.jalz.2014.03.002
Publication status	Published - Apr 2015
Externally published	Yes

Keywords

Age Distribution
Aged
Aged, 80 and over
Brain
Chi-Square Distribution
Cluster Analysis
Community Health Planning
Female
Frontotemporal Dementia
Humans
Male
Prevalence
Psychiatric Status Rating Scales
Retrospective Studies
Sex Distribution
Sweden
Tomography, X-Ray Computed
Journal Article
Research Support, Non-U.S. Gov't

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10.1016/j.jalz.2014.03.002

Cite this

@article{93be5fd2a89c46b79dbf3132b1890003,

title = "Effect of diagnostic criteria on prevalence of frontotemporal dementia in the elderly",

abstract = "BACKGROUND: Frontotemporal dementia (FTD) is believed to be rare in the elderly, and the influence of different criteria on the prevalence of FTD is unclear.METHODS: Population-based samples of 70- to 95-year-olds (n = 2462) in Gothenburg, Sweden, underwent neuropsychiatric examinations. Behavioral variant FTD (bvFTD) was diagnosed according to the International Behavioural Variant FTD Criteria Consortium (FTDC), the Frontotemporal Lobe Degeneration Consensus criteria, and the Lund-Manchester Research Criteria. A subset (n = 1074) underwent computerized tomography (CT) of the brain.RESULTS: The prevalence of bvFTD varied between 0.2\% and 0.5\% at age 70 to 79 years, between 2.5\% and 3.6\% at age 80 to 89 years, and between 1.7\% and 2.2\% at age 90 to 95 years. The agreement between different criteria was low to moderate (κ = 0.20-0.42). Among those with bvFTD according to FTDC, 93.3\% had frontal and/or temporal lobar atrophy on CT, compared with 12.6\% of those without bvFTD (P < .001).CONCLUSIONS: The prevalence of bvFTD was higher than expected in this population. To a large extent, different criteria captured different individuals.",

keywords = "Age Distribution, Aged, Aged, 80 and over, Brain, Chi-Square Distribution, Cluster Analysis, Community Health Planning, Female, Frontotemporal Dementia, Humans, Male, Prevalence, Psychiatric Status Rating Scales, Retrospective Studies, Sex Distribution, Sweden, Tomography, X-Ray Computed, Journal Article, Research Support, Non-U.S. Gov't",

author = "Gislason, \{Thorsteinn B\} and Svante {\"O}stling and Anne B{\"o}rjesson-Hanson and Magnus Sj{\"o}gren and Michela Simoni and Leonardo Pantoni and Ingmar Skoog",

year = "2015",

month = apr,

doi = "10.1016/j.jalz.2014.03.002",

language = "English",

volume = "11",

pages = "425--33",

journal = "Alzheimer's \& dementia : the journal of the Alzheimer's Association",

issn = "1552-5260",

publisher = "Elsevier Inc",

number = "4",

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TY - JOUR

T1 - Effect of diagnostic criteria on prevalence of frontotemporal dementia in the elderly

AU - Gislason, Thorsteinn B

AU - Östling, Svante

AU - Börjesson-Hanson, Anne

AU - Sjögren, Magnus

AU - Simoni, Michela

AU - Pantoni, Leonardo

AU - Skoog, Ingmar

PY - 2015/4

Y1 - 2015/4

N2 - BACKGROUND: Frontotemporal dementia (FTD) is believed to be rare in the elderly, and the influence of different criteria on the prevalence of FTD is unclear.METHODS: Population-based samples of 70- to 95-year-olds (n = 2462) in Gothenburg, Sweden, underwent neuropsychiatric examinations. Behavioral variant FTD (bvFTD) was diagnosed according to the International Behavioural Variant FTD Criteria Consortium (FTDC), the Frontotemporal Lobe Degeneration Consensus criteria, and the Lund-Manchester Research Criteria. A subset (n = 1074) underwent computerized tomography (CT) of the brain.RESULTS: The prevalence of bvFTD varied between 0.2% and 0.5% at age 70 to 79 years, between 2.5% and 3.6% at age 80 to 89 years, and between 1.7% and 2.2% at age 90 to 95 years. The agreement between different criteria was low to moderate (κ = 0.20-0.42). Among those with bvFTD according to FTDC, 93.3% had frontal and/or temporal lobar atrophy on CT, compared with 12.6% of those without bvFTD (P < .001).CONCLUSIONS: The prevalence of bvFTD was higher than expected in this population. To a large extent, different criteria captured different individuals.

AB - BACKGROUND: Frontotemporal dementia (FTD) is believed to be rare in the elderly, and the influence of different criteria on the prevalence of FTD is unclear.METHODS: Population-based samples of 70- to 95-year-olds (n = 2462) in Gothenburg, Sweden, underwent neuropsychiatric examinations. Behavioral variant FTD (bvFTD) was diagnosed according to the International Behavioural Variant FTD Criteria Consortium (FTDC), the Frontotemporal Lobe Degeneration Consensus criteria, and the Lund-Manchester Research Criteria. A subset (n = 1074) underwent computerized tomography (CT) of the brain.RESULTS: The prevalence of bvFTD varied between 0.2% and 0.5% at age 70 to 79 years, between 2.5% and 3.6% at age 80 to 89 years, and between 1.7% and 2.2% at age 90 to 95 years. The agreement between different criteria was low to moderate (κ = 0.20-0.42). Among those with bvFTD according to FTDC, 93.3% had frontal and/or temporal lobar atrophy on CT, compared with 12.6% of those without bvFTD (P < .001).CONCLUSIONS: The prevalence of bvFTD was higher than expected in this population. To a large extent, different criteria captured different individuals.

KW - Age Distribution

KW - Aged

KW - Aged, 80 and over

KW - Brain

KW - Chi-Square Distribution

KW - Cluster Analysis

KW - Community Health Planning

KW - Female

KW - Frontotemporal Dementia

KW - Humans

KW - Male

KW - Prevalence

KW - Psychiatric Status Rating Scales

KW - Retrospective Studies

KW - Sex Distribution

KW - Sweden

KW - Tomography, X-Ray Computed

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1016/j.jalz.2014.03.002

DO - 10.1016/j.jalz.2014.03.002

M3 - Journal article

C2 - 24954370

SN - 1552-5260

VL - 11

SP - 425

EP - 433

JO - Alzheimer's & dementia : the journal of the Alzheimer's Association

JF - Alzheimer's & dementia : the journal of the Alzheimer's Association

IS - 4

ER -

Effect of diagnostic criteria on prevalence of frontotemporal dementia in the elderly

Abstract

Keywords

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