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Effect of combination therapy with a calcium channel blocker and an angiotensin-converting enzyme inhibitor on renal hypertrophy and urinary albumin excretion in diabetic rats

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The objective of this study was to compare the effect of an angiotensin-converting enzyme (ACE) inhibitor and a calcium channel blocker on the development of renal changes in diabetic rats. Diabetes was induced by an intravenous injection of streptozotocin in normotensive Wistar rats. Treatment was commenced immediately in 1 set of rats with 4 treatment arms: nitrendipine (250 mg/kg fodder), enalapril (35 mg/L drinking water), both treatments in combination, or placebo. Treatment was continued for 9 weeks. Another set of rats was left with untreated diabetes for 3 months followed by 7 weeks treatment as above. When starting treatment right after induction of diabetes, nitrendipine significantly reduced urinary albumin excretion (UAE) to the nondiabetic level (P < .05) without reducing blood pressure (BP), whereas enalapril failed to significantly reduce UAE despite a reduction in BP. Combining the two treatments showed no further reduction in UAE compared to monotherapy with nitrendipine, despite a lower BP. When leaving diabetic rats untreated for 3 months, only the coadministration of nitrendipine and enalapril showed a significant reduction in UAE compared to monotherapy and placebo treatment, but showed no significant effect on BP.

Original languageEnglish
JournalExperimental Diabesity Research
Issue number3
Pages (from-to)191-9
Number of pages9
Publication statusPublished - 6 Apr 2004
Externally publishedYes

    Research areas

  • Albuminuria, Angiotensin-Converting Enzyme Inhibitors, Animals, Calcium Channel Blockers, Diabetes Mellitus, Type 1, Diabetic Nephropathies, Drug Therapy, Combination, Enalapril, Female, Kidney, Nitrendipine, Rats, Rats, Wistar, Journal Article, Research Support, Non-U.S. Gov't

ID: 51976826